Amino-PEG4-acid
- CAS No.
- 663921-15-1
- Chemical Name:
- Amino-PEG4-acid
- Synonyms
- 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid;NH2-PEG4-COOH;Amino-PEG4-acid;NH2-PEG4-CH2CH2COOH;3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid;NH2-PEG4-PA;Amino-PEG4-COOH;AMINE-PEG4-COOH;amino-dPEG4-acid;Amino-dPEGx-acid
- CBNumber:
- CB92501434
- Molecular Formula:
- C11H23NO6
- Molecular Weight:
- 265.3
- MOL File:
- 663921-15-1.mol
- Modify Date:
- 2024/4/8 13:48:25
| Boiling point | 409.6±40.0 °C(Predicted) |
|---|---|
| Density | 1.134±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.28±0.10(Predicted) |
| form | powder |
| color | White |
| InChI | InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14) |
| InChIKey | DKUZHSDZSMQOGQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCCOCCOCCOCCN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P261 |
| HS Code | 2942000090 |
Amino-PEG4-acid Chemical Properties,Uses,Production
Uses
H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.
benefits
Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
References
1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p
Amino-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| airuikechemical co., ltd. | +undefined86-15315557071 | China | 983 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| ChemExpress | +86-021-58950125 | China | 598 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13187 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| airuikechemical co., ltd. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| ChemExpress | 58 |
| Henan Alfa Chemical Co., Ltd | 58 |
| Nextpeptide Inc | 58 |
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