Voriconazole-d3

CAS No.: 188416-29-7

Chemical Name:: Voriconazole-d3

Synonyms: 3R)-2-(2;VORICONAZOLE-D3;Voriconazole PI-6;(2R,3R)-Voriconazole;Voriconazole Intermediate II;Intermediate 2 of voriconazole;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1;(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

CBNumber:: CB92610550

Molecular Formula:: C16H14F3N5O

Molecular Weight:: 349.31

MOL File:: 188416-29-7.mol

Modify Date:: 2023/6/1 14:25:53

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Voriconazole-d3 Properties

Boiling point	508.6±60.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
pka	11.54±0.29(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Voriconazole-d3 Chemical Properties,Uses,Production

Description

Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.

Uses

Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.

Application

Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.

References

1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Voriconazole-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

Voriconazole-d3 Suppliers

Global( 72)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
HAINAN POLY PHARMCEUTICAL CO. LTD	+86-0571-89385087 +8613616530509	China	118	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18642	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1320	58	Inquiry
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	China	13341	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry
sgtlifesciences pvt ltd	+8617013299288	China	12382	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	China	25363	58	Inquiry

Supplier	Advantage
HAINAN POLY PHARMCEUTICAL CO. LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
AFINE CHEMICALS LIMITED	58
sgtlifesciences pvt ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

188416-29-7(Voriconazole-d3)Related Search:

4-Ethyl-5-fluoropyrimidine Voriconazole Impurity 16 Ethanone, 1-(3,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI)

Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- 1,2,4-Triazole Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

ent-Voriconazole FENOFIBRIC ACID ETHYL ESTER (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine

2-Chloro-2',4'-difluoroacetophenone

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(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Voriconazole PI-6 (2R,3R)-Voriconazole (R *, S *) 3- (5-fluoropyrimidin-4-yl) -2- (2,4-difluorophenyl) -1- (1H-1,2,4-triazol-1-yl ) -2-butanol (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol 3R)-2-(2 4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1 4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)ChemicalBook 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel- (2R, 3S/2S, 3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophyenyl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol {Racemic Voriconazole} VORICONAZOLE-D3 Voriconazole Intermediate II Intermediate 2 of voriconazole 188416-29-7