Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- CAS No.
- 1195768-19-4
- Chemical Name:
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Synonyms
- DABRAFENIB INT;Dalafenib intermediate 3;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate;Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
- CBNumber:
- CB92703779
- Molecular Formula:
- C14H10F3NO4S
- Molecular Weight:
- 345.29
- MOL File:
- 1195768-19-4.mol
- Modify Date:
- 2024/5/24 18:18:52
| Boiling point | 445.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.507±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 6.68±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C14H10F3NO4S/c1-22-14(19)8-4-2-7-11(12(8)17)18-23(20,21)13-9(15)5-3-6-10(13)16/h2-7,18H,1H3 |
| InChIKey | COSCWKICERLCEK-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=CC(NS(C2=C(F)C=CC=C2F)(=O)=O)=C1F |
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Chemical Properties,Uses,Production
Synthesis
Methyl 3-amino-2-fluorobenzoate was charged to the reactor, followed by dichloromethane. The contents were stirred and cooled to ~15°C, and pyridine was added. After that, the reactor contents were adjusted to ~15°C, and adding 2,6-diflurorobenzenesulfonyl chloride was started via an addition funnel. The temperature during addition was kept at <25°C. After complete addition, the reactor contents were warmed to 20-25°C and held overnight. Ethyl acetate was added, and dichloromethane was removed by distillation. Once distillation was complete, the reaction mixture was diluted again with ethyl acetate (5 vol) and concentrated. Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate was obtained through further purification.![Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate](/NewsImg/2023-12-06/6383747428389984808211694.jpg "Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate")
storage
Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | China | 46 | 58 | Inquiry |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | China | 57 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | China | 1377 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |