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AS1842856

AS1842856 Structure
CAS No.
836620-48-5
Chemical Name:
AS1842856
Synonyms
CS-2538;AS1842856;AS 1842856;AS-1842856;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
CBNumber:
CB93122441
Molecular Formula:
C18H22FN3O3
Molecular Weight:
347.38
MOL File:
836620-48-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:41
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AS1842856 Properties

Boiling point 587.3±50.0 °C(Predicted)
Density 1.370±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO:5.0(Max Conc. mg/mL);14.39(Max Conc. mM)
form A crystalline solid
pka 6.47±0.50(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H410-H372
Precautionary statements  P260-P264-P273-P501
NFPA 704
0
2 0

AS1842856 Chemical Properties,Uses,Production

Description

AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.,

AS1842856 Preparation Products And Raw materials

Raw materials

3-Quinolinecarboxylic acid, 1-ethyl-5,6,7-trifluoro-1,4-dihydro-4-oxo-, ethyl ester 3-Quinolinecarboxylic acid, 5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester 3-Quinolinecarboxylic acid, 5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo- 3,4,5-Trifluoroaniline Cyclohexylamine

Preparation Products

AS1842856 Suppliers

Global( 81)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd +86-18341751992 +86-15382112998 China 892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 5225 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Zhengzhou Acme Chemical Co., Ltd. 0371-0371-55629727 13323845623 China 9857 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58
Zhengzhou Acme Chemical Co., Ltd. 58

AS1842856 Spectrum

AS1842856(836620-48-5)1HNMR

836620-48-5(AS1842856)Related Search:

Butyl ethyl ether 1-Cyclohexylethanol
AS1842856 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid CS-2538 AS 1842856;AS-1842856 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo- 836620-48-5