1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
- CAS No.
- 56602-33-6
- Chemical Name:
- 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
- Synonyms
- BOP;BOP REAGENT;BENZOTRIAZOL-1-YLOXYTRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE;1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide];cas:56602-33-6;BOP-reaagent;CASTROS REAGENT;CASTRO'S REAGENT;BOP Reagent(BOP);BOP, Castros Reagent
- CBNumber:
- CB9434718
- Molecular Formula:
- C12H22F6N6OP2
- Molecular Weight:
- 442.29
- MOL File:
- 56602-33-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/16 12:01:05
Melting point | >130 °C (dec.)(lit.) |
---|---|
Flash point | 138°C |
storage temp. | 2-8°C |
solubility | methanol: 25 mg/mL, clear |
form | Powder |
color | White to off-white |
Water Solubility | Soluble in methanol, acetone and dichloromethane. Insoluble in water. |
Sensitive | Moisture & Light Sensitive |
Decomposition | 138 ºC |
BRN | 4287025 |
CAS DataBase Reference | 56602-33-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H228-H315-H335 | |||||||||
Precautionary statements | P210-P240-P241-P261-P264-P302+P352 | |||||||||
Hazard Codes | Xi,E,F | |||||||||
Risk Statements | 37/38-44-36/37/38-11-2 | |||||||||
Safety Statements | 24/25-37/39-36-26-35-36/37/39 | |||||||||
RIDADR | UN 1325 4.1/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
F | 8-10-21 | |||||||||
Hazard Note | Irritant | |||||||||
HazardClass | 4.1 | |||||||||
PackingGroup | Ⅱ | |||||||||
HS Code | 29339980 | |||||||||
NFPA 704 |
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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 8.51004 | BOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem? | 56602-33-6 | 25G | ₹6570 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.51004 | BOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem? | 56602-33-6 | 100G | ₹21800 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 226084 | (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 97% | 56602-33-6 | 1G | ₹1667.05 | 2022-06-14 | Buy |
Sigma-Aldrich | 226084 | (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 97% | 56602-33-6 | 5G | ₹2478.93 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 226084 | (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 97% | 56602-33-6 | 5G | ₹2478.93 | 2022-06-14 | Buy |
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder
Uses
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.
Purification Methods
Dissolve it in CH2Cl2, dry (MgSO4), filter, concentrate it under a vacuum, then add dry Et2O and filter off the first crop. Add CH2Cl2 to the filtrate and concentrate again to obtain a second crop. The solid is washed with dry Et2O and dried in a vacuum. Also recrystallise it from dry Me2CO/Et2O and check the purity by NMR. Store it in the dark. [Castro et al. Synthesis 751 1976, Nguyen et al J Chem Soc, Perkin Trans I 1915 1987, Coste et al. Tetrahedron Lett 36 4253 1995.]
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
NSJ Prayog Life Sciences Private Limited | +91-6281747900 +91-6281747900 | Hyderabad, India | 76 | 58 | Inquiry |
ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
Sisco Resech Laboratories Private Limited | +91-22-4268 5800 | Mumbai, India | 655 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Spectrum
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