Mesterolone
- CAS No.
- 1424-00-6
- Chemical Name:
- Mesterolone
- Synonyms
- proviron;mesterolon;MESTERELONE;testiwop;sh723;NSC-7504;NSC 75054;mestoranum;mesteranum;androviron
- CBNumber:
- CB9691874
- Molecular Formula:
- C20H32O2
- Molecular Weight:
- 304.47
- MOL File:
- 1424-00-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/24 16:40:18
| Melting point | 208 °C |
|---|---|
| alpha | D20 +17.6° (c = 0.875 in CHCl3) |
| Boiling point | 420.3±45.0 °C(Predicted) |
| Density | 1.156 g/cm3 |
| refractive index | 17.6 ° (C=0.9, CHCl3) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, sparingly soluble in acetone, in ethyl acetate and in methanol |
| pka | 15.09±0.70(Predicted) |
| Water Solubility | 3mg/L at 20℃ |
| Merck | 5916 |
| InChI | InChI=1/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/s3 |
| InChIKey | UXYRZJKIQKRJCF-TZPFWLJSSA-N |
| SMILES | [C@@]12([H])CC[C@@]3([H])CC(=O)C[C@H](C)[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])O |&1:0,4,10,12,14,18,20,23,r| |
| CAS DataBase Reference | 1424-00-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H351-H360FD-H362-H411 | |||||||||
| Precautionary statements | P202-P260-P263-P264-P273-P308+P313 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/21/22-38-19-11-61-60 | |||||||||
| Safety Statements | 22-24/25-36/37/39-45-53 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BV8063400 | |||||||||
| HS Code | 29372900 | |||||||||
| DEA Controlled Substances | CSCN: 4000 CSA SCH: Schedule III NARC: No |
|||||||||
| NFPA 704 |
|
Mesterolone Chemical Properties,Uses,Production
Description
Mesterolone (Item No. 21171) is an analytical reference standard categorized as an anabolic androgenic steroid. Formulations containing mesterolone have been used in patients with low testosterone or symptoms of aging male syndrome. Mesterolone cannot be aromatized to estrogens, unlike other androgens. This compound is the active ingredient in different pharmaceutical preparations that have been used medically but have also been widely applied in sports in order to improve athlete performance. Mesterolone is regulated as a Schedule III drug in the United States. This product is intended for research and forensic applications.
Chemical Properties
White or yellowish crystalline powder.
Uses
Mesterolone is a synthetic androgen and a dihydrotestosterone derivative. Mesterolone is rarely used for replacement therapies due to its weak androgenic activity.
Definition
ChEBI: Mesterolone is a 3-oxo-5alpha-steroid. It is a structurally altered DHT hormone possessing the addition of a methyl group at the carbon one position. This allows the hormone to survive oral ingestion by protecting it from hepatic breakdown. This is one of the only oral anabolic steroids that is not C17-alpha alkylated (C17-aa) but instead carries the added methyl group.
Application
Mesterolone is a pharmacological agent that belongs to the group of androgens. It is an oral preparation and has been used in the treatment of infectious diseases, autoimmune diseases, and metabolic disorders. It has also been used as a matrix effect control in biological samples. The biological effects of it are mediated by its direct action on cells or through conversion to testosterone or dihydrotestosterone (DHT). These effects include increasing protein synthesis, promoting bone formation, lowering cholesterol levels, stimulating the production of red blood cells, and decreasing fat deposition.
General Description
Mesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is inactivated by 3α-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. It is not a substrate for aromatase so it is not converted into estrogen. Mesterolone demonstrated to have minimal effect on sperm counts and levels of FSH or LH. Experiments of mesterolone serving as a potential treatment of depression are still undergoing.
Side effects
The main side effects are acne vulgaris, male pattern baldness, prostate enlargement, increased risk for prostate cancer, and increased risk for developing breast cancer.
Mesterolone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| Shakti Life Science | +91-9930420063 +91-9930420063 | Maharashtra, India | 28 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Homme Pharma | 08048250259Ext 923 | Mumbai, India | 4 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Horster Biotek Pvt Ltd | 58 |
| Shakti Life Science | 58 |
| Ralington Pharma | 58 |
| OCEAN TRADING CORPORATION | 58 |
| Medilink Pharmachem | 50 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Homme Pharma | 58 |
| Indogulf Group | 58 |
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- Synthesis and Bioactivity of Mesterolone
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