Nitroxoline
- CAS No.
- 4008-48-4
- Chemical Name:
- Nitroxoline
- Synonyms
- 5-NITRO-8-HYDROXYQUINOLINE;Nitroxolin;Niroxoline;8-HYDROXY-5-NITROQUINOLINE;5nok;A-82;5-NOK;bas58;Noxin;Nibiol
- CBNumber:
- CB9711910
- Molecular Formula:
- C9H6N2O3
- Molecular Weight:
- 190.16
- MOL File:
- 4008-48-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/26 14:09:12
| Melting point | 181-183 °C(lit.) |
|---|---|
| Boiling point | 325.64°C (rough estimate) |
| Density | 1.3907 (rough estimate) |
| refractive index | 1.5570 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | alcohol: very slightly soluble |
| pka | 2.55±0.10(Predicted) |
| form | powder to crystal |
| color | Light yellow to Brown to Dark green |
| Merck | 14,6655 |
| NIST Chemistry Reference | 8-Hydroxy-5-nitroquinoline(4008-48-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319-H335 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 23/24/25-36/37/38-22/24/25-20/21/22 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VC8225000 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29334900 | |||||||||
| Toxicity | LD50 oral in rat: 510mg/kg | |||||||||
| NFPA 704 |
|
Nitroxoline price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 140325 | 8-Hydroxy-5-nitroquinoline 96% | 4008-48-4 | 5G | ₹3106.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 140325 | 8-Hydroxy-5-nitroquinoline 96% | 4008-48-4 | 5G | ₹3106.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0805 | 8-Hydroxy-5-nitroquinoline min. 98.0 % | 4008-48-4 | 25G | ₹7300 | 2022-05-26 | Buy |
| ALFA India | ALF-B24462-06 | 8-Hydroxy-5-nitroquinoline, 96% | 4008-48-4 | 5g | ₹1655 | 2022-05-26 | Buy |
Nitroxoline Chemical Properties,Uses,Production
Description
Nitroxoline is an 8-hydroxyquinoline that has diverse biological activities, including antibacterial, antiproliferative, and bromodomain interaction-inhibiting properties. Nitroxoline is active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively). It also inhibits biofilm formation of certain strains of multidrug-resistant (MDR) A. baumannii and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) with minimum biofilm eradication concentration (MBEC) values of 46.9, 1,500, 188, and 125 μM, respectively. Nitroxoline inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively). In vivo, it reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model when administered at a dose of 80 mg/kg per day. Nitroxoline also inhibits the interaction between the first bromodomain of bromodomain-containing protein 4 (BRD4) with acetylated histone H4 with an IC50 value of 0.98 μM.
Chemical Properties
ochre-yellow to brownish crystalline powder
Uses
antibacterial
Definition
ChEBI: A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.
World Health Organization (WHO)
Nitroxoline, a urinary antiseptic, was introduced in the mid-1960s. By the early 1970s long-term animal studies revealed the development of cataracts in rats and, although no serious adverse effects had been reported in man, the drug was withdrawn in at least two countries. Preparations containing nitroxoline remain widely available.
Nitroxoline Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SURVIVAL TECHNOLOGIES LIMITED | +91 8108285261 | Gujarat, India | 294 | 58 | Inquiry |
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Kopran Ltd | +91-9920289074 +91-9820220525 | Maharashtra, India | 21 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Auro Pharmaceuticals And Fine Chemicals Pvt Ltd | +91-2024475340 +91-8087324189 | Maharashtra, India | 25 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
4008-48-4(Nitroxoline)Related Search:
1of4
chevron_right