Argatroban
- CAS No.
- 141396-28-3
- Chemical Name:
- Argatroban
- Synonyms
- Argatroban Monohydrate;(2r,4r)-4-methyl-1-[n-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl]-2-piperidinecarboxylic acid;GN1600;AG, SAJ;CS-1966;US-DMF：035491;Argatroban API;Acova monohydrate;Argatroban (350 mg);API Cas:141396-28-3
- CBNumber:
- CB9738829
- Molecular Formula:
- C23H38N6O6S
- Molecular Weight:
- 526.65
- MOL File:
- 141396-28-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/11 15:49:39
| Melting point | 176-180° |
|---|---|
| alpha | D27 +76.1° (c = 1 in 0.2N HCl) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | Solid |
| color | white to off-white |
| Merck | 14,779 |
| CAS DataBase Reference | 141396-28-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H223+H229 |
| WGK Germany | 3 |
| RTECS | TM6126610 |
| HS Code | 29350090 |
| Toxicity | mouse,LD50,intraperitoneal,475mg/kg (475mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABLOOD: NORMOCYTIC ANEMIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
Argatroban price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A0487 | Argatroban monohydrate ≥98% (HPLC) | 141396-28-3 | 5MG | ₹8540.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0487 | Argatroban monohydrate ≥98% (HPLC) | 141396-28-3 | 25MG | ₹34401.85 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2705 | Argatroban Monohydrate | 141396-28-3 | 25MG | ₹16000 | 2022-05-26 | Buy |
Argatroban Chemical Properties,Uses,Production
Uses
Argatroban monohydrate has been used as a thrombin-selective inhibitor in the thrombin assay of platelet poor plasma samples. It may be used as a standard in gradient reversed-phase liquid chromatography coupled with high-resolution multistage mass spectrometry (LC/HR-MSn) for photoproducts fragmentation analysis and as a thrombin inhibitor competitive assay with fullerene-based C60 nanoparticle (NPs).
General Description
Argatroban anticoagulant is synthesized from L-arginine and photodegrades under light exposure.
Enzyme inhibitor
This anticoagulant (FW = 508.64 g/mol; CAS 74863-84-6), also named (2R,4R) -4-methyl-1-N2-[ (3-methyl-1,2,3,4-tetrahydro-8-quinolilyl) sulfon- yl]-L-arginyl-2-piperidine carboxylic acid, Novastan?, and MD-805, is a direct thrombin inhibitor (1-11) that is an effective treatment for heparin- induced thrombocytopenia (HIT), an immunoglobulin-mediated adverse drug reaction characterized by platelet activation, thrombocytopenia, and a high risk of thrombotic complications among patients who are receiving or have recently received heparin. HIT is an autoimmune-like disorder, with the target antigen a multimolecular complex of the “self” protein, Platelet Factor-4, and heparin. Continued use of heparin is ill-advised and dangerous. Argatroban is also indicated for the treatment of heparin- induced thrombocytopenia and thrombosis syndrome (HITTS), an immune- mediated response to the administration of heparin that results in life- threatening thrombosis. Argatroban is one of four FDA-approved parenteral direct thrombin inhibitors, the others being lepirudin, desirudin, and bivalirudin. Argatroban is metabolized in the liver (t1/2 = ~50 min). Other DTI’s include recombinant hirudins, bivalirudin, and ximelagatran, either alone or in combination with melagatran. Argatroban is a significantly weaker inhibitor of trypsin, K = 4.3 μM, plasmin (K = ii 800 μM), coagulation factor Xa, and plasma kallikrein (Ki = 2 mM). Commercial sources often supply a mixture of 21 (R) and 21 (S) Diastereoisomers. The latter is more potent.
Argatroban Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Apothecon Pharmaceuticals Pvt Ltd | +91-2662244212 +91-9099007601 | Gujarat, India | 28 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |