トロンボポエチン,ヒト,組換え体 化学特性,用途語,生産方法
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特長
≪アニマルフリーサイトカイン≫ 本品は動物由来原料を使用せず培養・発現させて得た組換え体のサイトカインです。
特長
≪アニマルフリーサイトカイン≫ 本品は動物由来原料を使用せずに培養・発現させて得た組換え体のサイトカインです。
使用上の注意
本品は微量の為内容物を視認できないことがあります。蓋を開ける前は必ず遠心して下さい。
使用上の注意
本品は微量のため内容物を視認できないことがあります。蓋を開ける前は必ず遠心して下さい。
使用
TPO stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets
Biochem/physiol Actions
Thrombopoeitin is a primary regulatory factor for megakaryocytopoiesis and thrombopoiesis. The mature form of TPO is a highly conserved glycoprotein, showing homology among various mammals. It is produced by liver and kidney cells. TPO stimulates growth and maturation of megakaryocytes and megakaryocytic colonies from bone marrow cultures. TPO binds and activates an 68-78 kDa glycoprotein receptor belonging to the GH family of cytokine receptors, a family that includes receptors to growth hormone (GH), erythropoietin (EPO), and prolactin (PRL). Like GH and EPO, TPO may bind to its receptor at two distinct sites, initiating receptor dimerization and activation. Analysis of mRNA indicates also the existence of a novel truncated and potentially soluble form of TPO receptor. The viral oncogene v-mlp of the myeloproliferative leukemia virus (MPLV) contains the gene sequence for the entire cytoplasmic and transmembrane domains and a portion of the extracellular domain of c-mlp (TPO receptor).
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