3-[(R)-2-ヒドロキシ-3-メチルブチル]-4,8-ジメトキシ-1-メチル-2(1H)-キノリノン 化学特性,用途語,生産方法
説明
This alkaloid was first described by Boorsma who obtained it from the bark of
Lunasia costulata Miq (Syn. L. amara Blanco). The base is a quinolone derivative
and crystallizes as colourless needles from AcOEt. It is dextrorotatory having
[α]
24D + 30.1 ° and [α]
24436 + 81.8°. Boorsma gives a specific rotation of [α]
28D +
31.6°. The solutions of the alkaloid show a weak blue fluorescence in artificial
light. A crystalline perchlorate is known, m.p. 146-8°C and 193-5°C after
intermediate solidification. This salt is also dextrorotatory with [α]
2558925
436+ 60.7°. The structure has been demonstrated to be 3-(2-hydroxy-3-
methylbutyl)-4: 8-dimethoxy-l-methyl-2-quinolone. The alkaloid described
under this name by Dieterle and Beyl appears to be identical with lunamarine
(q.v.).
参考文献
Boorsma., Meded. Lands. Plant., 31, 13, 126 (1899)
Boorsma.,Bull. Inst. Bot. Buit., No. 31, 8, 25 (1904)
Dieterle, Beyl., Arch. Pharm., 275, 174 (1937)
Steldt, Chen.,J. Amer. Pharm. Assoc., 32, 107 (1943)
Goodwin, Horning.,J. Amer. Chem. Soc., 81, 1908 (1959)
Clarke, Grundon., Chem. & Ind., 556 (1962)
Clarke, Grundon.,J. Chem. Soc., 438 (1964)
3-[(R)-2-ヒドロキシ-3-メチルブチル]-4,8-ジメトキシ-1-メチル-2(1H)-キノリノン 上流と下流の製品情報
原材料
準備製品