Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来
Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 物理性質
- 貯蔵温度 :
- -20°C
- 外見 :
- 緩衝グリセロール水溶液
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H412 |
長期的影響により水生生物に有害 |
水生環境有害性、慢性毒性 |
3 |
|
|
P273, P501 |
|
| 注意書き |
| P273 |
環境への放出を避けること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 価格
もっと(4)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
K1502 |
α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry)
α-Ketoglutarate Dehydrogenase from porcine heart buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry) |
9031-02-1 |
20units |
￥59300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
K1502 |
α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry)
α-Ketoglutarate Dehydrogenase from porcine heart buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry) |
9031-02-1 |
50units |
￥70100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
K1502 |
α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry)
α-Ketoglutarate Dehydrogenase from porcine heart buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry) |
9031-02-1 |
50un |
￥88000 |
2018-12-25 |
購入 |
|
Sigma-Aldrich Japan
|
K1502 |
α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry)
α-Ketoglutarate Dehydrogenase from porcine heart buffered aqueous glycerol solution, 0.1-1.0?units/mg protein (Lowry) |
9031-02-1 |
20un |
￥45000 |
2018-12-25 |
購入 |
Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 化学特性,用途語,生産方法
使用
α-Ketoglutarate Dehydrogenase from the porcine heart has been used:
- to study the reversal of nitration by glutathione (GSH) in peroxynitrite-treated cells
- to measure its activity by Spectramax M5 microplate spectrofluorimeter using heart mitochondria
- as a positive control to evaluate its activity in by Spectramax GEMINI EM fluorescence microplate reader using mice neurons
一般的な説明
α-Ketoglutarate dehydrogenase (α-KGDH) is a multienzyme complex localized to the mitochondria. This integrated enzyme is made up of many units of thiamine pyrophosphate-dependent dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3), and dihydrolipoamide succinyl transferase (E2).
Biochem/physiol Actions
α-Ketoglutarate dehydrogenase (α-KGDH) is a key enzyme of bioenergetic processes and a controlling unit of metabolic flux through the Krebs cycle or tricarboxylic acid (TCA) cycle. It catalyzes the oxidative decarboxylation of α-ketoglutarate (KG) to succinyl-CoA by releasing reduced nicotinamide adenine dinucleotide (NADH). It is the rate-limiting reaction of the TCA cycle. This reaction contributes to the electrons of the respiratory chain and requires thiamine pyrophosphate as a cofactor. The reduction of NAD (nicotinamide adenine dinucleotide) is observed to determine its reaction rate. α-KGDH from porcine has an optimum pH range of 6.6–7.4. This enzyme is inhibited by oxidative stress and results in a metabolic deficiency. However, α-KGDH is also known to produce reactive oxygen species (ROS) leading to oxidative stress. Defective or limited levels of α-KGDH cause several neurodegenerative diseases such as Alzheimer′s disease.
Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 上流と下流の製品情報
原材料
準備製品
Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来 生産企業
Global( 7)Suppliers
- 9031-02-1
- ALPHA-KETOGLUTARATE DEHYDROGENASE
- A-ketoglutarate dehydrogenase from*porcine heart
- multienzyme 2-oxoglutarate dehydrogenase complex
- α-ketoglutarate dehydrogenase from porcine heart
- MULTIENZYME 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, (1) INCLUDING EC 1.2.4.2
- α-Ketoglutarate Dehydrogenase
- alpha-Ketoglutarate Dehydrogenase from porcine heart
- α-Ketoglutarate Dehydrogenase, from porcine heart
- Α-ケトグルタル酸デヒドロゲナーゼ ブタ心臓由来