7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩

7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩 価格 もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	SML2098	≥98% (HPLC) KINK-1 hydrochloride ≥98% (HPLC)	600734-06-3	5mg	￥32700	2024-03-01	購入
Sigma-Aldrich Japan	SML2098	≥98% (HPLC) KINK-1 hydrochloride ≥98% (HPLC)	600734-06-3	25mg	￥128000	2024-03-01	購入

7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩 化学特性,用途語,生産方法

Biochem/physiol Actions

KINK-1 (Kinase Inhibitor of NF-ΚB-1; Bay 65-1942; CmpdA; Compound A) is an ATP-competitive, IKKβ-selective IΚB kinase (IKK) inhibitor (Ki against ATP = 2 nM/IKKβ and 135 nM/IKKα) that potently inhibits IKKβ-catalyzed GST-IΚBα(1–54) phosphorylation (IC50 = 4 nM, 200 nM ATP) without affecting (IC50 >10μM) IKK3 or 27 other kinases, lipases, phosphatases, caspases, and MMPs. KINK-1 effectively inhibits NF-ΚB activation and cytokines production in various human and murine cultures (IC50 from 18 to 502 nM) and is efficacious against LPS-induced plasma TNF-α production in mice and rats in vivo (EC50 = 9.1 and 6.6 mg/kg p.o., repectively) with good pharmacokinetic profile and oral availability. KINK-1 is also shown to effectively inhibit OVA-induced lung inflammation in a rat model of asthma (ED50 <0.3 mg/kg p.o.) without adverse effects to the animals.

7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩 上流と下流の製品情報

原材料

準備製品

7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55

600734-06-3(7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩)キーワード:

---

• 600734-06-3
• Bay 65-1942 (HCl salt)
• Bay 65-1942 HCl
• Bay 65-1942 (hydrochloride)
• (S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride
• 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
• 2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)
• KINK-1 hydrochloride >=98% (HPLC)
• KINK-1 hydrochloride
• Bay 651942 hydrochloride,Bay 65 1942 hydrochloride
• 7-[2-(シクロプロピルメトキシ)-6-ヒドロキシフェニル]-1,4-ジヒドロ-5-[(3S)-3-ピペリジニル]-2H-ピリド[2,3-d][1,3]オキサジン-2-オン・塩酸塩