NBI 35965 hydrochloride
NBI 35965 hydrochloride 物理性質
- 融点 :
- 167 °C
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- Soluble in DMSO > 10 mM
- 外見 :
- Powder
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
NBI 35965 hydrochloride 価格
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NBI 35965 hydrochloride 化学特性,用途語,生産方法
使用
Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo. In animal models of stress, NBI 35965 administration produces anxiolytic effects.[Cayman Chemical]
NBI 35965 hydrochloride 上流と下流の製品情報
原材料
準備製品
NBI 35965 hydrochloride 生産企業
Global( 23)Suppliers
- 603151-83-3
- NBI 35965 hydrochloride
- NBI-35965 Mesylate