Chinese english Germany Korea

MRK560

MRK560 化学構造式
677772-84-8
CAS番号.
677772-84-8
化学名:
MRK560
别名:
MRK560
英語名:
MRK 560
英語别名:
MRK 560;MRK-560; MRK560;WDZVWDXOIGQJIO-UJKQEGAGSA-N;N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide;Methanesulfonamide, N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-;N-((1s,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide;MRK-560,Jurkat cells,DND-41,Aβ peptides,MRK560,MRK 560,Gamma secretase,γ-secretase,T-ALL,Inhibitor,inhibit,Alzheimer’s disease,HPB-ALL
CBNumber:
CB02538282
化学式:
C19H17ClF5NO4S2
分子量:
517.92
MOL File:
677772-84-8.mol
MSDS File:
SDS

MRK560 物理性質

沸点 :
580.1±60.0 °C(Predicted)
比重(密度) :
1.57±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at 4°C
溶解性:
<51.79mg/ml in DMSO; <25.9mg/ml in ethanol
外見 :
solid
酸解離定数(Pka):
5.97±0.40(Predicted)
色:
White

安全性情報

MRK560 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC4000 MRK560
MRK 560 		677772-84-8 10mg ￥86000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC4000 MRK560
MRK 560 		677772-84-8 50mg ￥361000 2024-03-01 購入

MRK560 化学特性,用途語,生産方法

説明

MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer''s disease.

使用

MRK 560 acts as a y-secretase inhibitor that is orally bioavailable and potent and may be used in a therapeutic strategy to counter low amyloid (β) production in Alheimer’s disease.

MRK560 上流と下流の製品情報

原材料

準備製品

MRK560 生産企業

Global( 38)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185
 sales-cpd@caerulumpharma.com China 3453 58
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772
 huahero21@sina.com China 376 55
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2987 58
Shanghai zhigan biotechnology co., LTD
zhiqianbio@126.com China 19785 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58

MRK560  スペクトルデータ(1HNMR)

MRK 560(677772-84-8)1HNMR
  • 677772-84-8
  • N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
  • N-((1s,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide
  • MRK 560
  • Methanesulfonamide, N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-
  • MRK-560; MRK560
  • WDZVWDXOIGQJIO-UJKQEGAGSA-N
  • MRK-560,Jurkat cells,DND-41,Aβ peptides,MRK560,MRK 560,Gamma secretase,γ-secretase,T-ALL,Inhibitor,inhibit,Alzheimer’s disease,HPB-ALL
  • MRK560
Copyright 2017 © ChemicalBook. All rights reserved