(S)-Lisofylline 化学特性,用途語,生産方法
説明
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-
inflammatory agent. (S)-
LSF is the pharmacologically inactive optical enantiomer of (R)-
LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-
LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-
LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
使用
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.[Cayman Chemical]
(S)-Lisofylline 上流と下流の製品情報
原材料
準備製品