ロミタピドメシル酸塩
ロミタピドメシル酸塩 物理性質
- 貯蔵温度 :
- Inert atmosphere,Room Temperature
- 溶解性:
- DMSO:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
- 外見 :
- Solid
- 色:
- White to off-white
- CAS データベース:
- 202914-84-9
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H351 |
発がんのおそれの疑い |
発がん性 |
2 |
警告 |
|
P201, P202, P281, P308+P313, P405,P501 |
| H360 |
生殖能または胎児への悪影響のおそれ |
生殖毒性 |
1A, 1B |
危険 |
|
|
| H413 |
長期的影響により水生生物に有害のおそれ |
水生環境有害性、慢性毒性 |
4 |
|
|
|
|
| 注意書き |
| P201 |
使用前に取扱説明書を入手すること。 |
| P202 |
全ての安全注意を読み理解するまで取り扱わないこ と。 |
| P281 |
指定された個人用保護具を使用すること。 |
| P308+P313 |
暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。 |
| P405 |
施錠して保管すること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
ロミタピドメシル酸塩 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
ロミタピドメシル酸塩 化学特性,用途語,生産方法
効能
脂質異常症治療薬, ミクロソームトリグリセリド輸送タンパク(MTTP)阻害薬
商品名
ジャクスタピッド (AEGERION PHARMACEUTICALS)
説明
Lomitapide is an orally active microsomal triglyceride transfer
protein (MTP) inhibitor for the treatment of hypercholesterolemia.
The drug was developed by Aegerion
Pharmaceuticals Inc. and licensed to Bristol–Myers Squibb Co.
and the University of Pennsylvania. Lomitapide effectively lowered
LDL–cholesterol, both as a single agent and in combination
with commonly prescribed lipid-lowering therapies. Sold under
the trade name Juxtapid, the drug offers a new treatment option
to patients who cannot tolerate statin therapy or who experience
insufficient LDL–cholesterol reduction with the currently available
therapies, such as patients with homozygous familial hypercholesterolemia
caused by mutations in the LDLR gene.
定義
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
合成
Commercial 9H-fluorene-9-carboxylic acid (105) was alkylated
with 1,4-dibromobutane in the presence of n-butyl lithium in
THF to give 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid
(106) in 85% yield. Next, activation of the acid as the acid chloride
followed by coupling with (2,2,2-trifluoroethylamine) provided
amide 107 in 71% yield for the two-step sequence. Displacement
of the terminal bromide with the appropriate 4-carbamoyl
piperidine followed by removal of the Boc group furnished piperidinyl
fluorine 108 in high yield. Amine 108 was then reacted with
the acid chloride derived from acid 109 (derived from the Suzuki
coupling of boronic acid 110 and o-iodobenzoic acid 111) to give
lomitapide, and this was followed by salt formation with methanesulfonic
acid to afford lomitapide mesylate (XIV).
ロミタピドメシル酸塩 上流と下流の製品情報
原材料
準備製品
ロミタピドメシル酸塩 生産企業
Global( 72)Suppliers
202914-84-9(ロミタピドメシル酸塩)キーワード:
- 202914-84-9
- BMS 201038-04
- LoMitapide Mesylate
- BMS 201038 methanesulfonic acid salt
- AEGR 733 Mesylate
- AEGR733 Mesylate
- AEGR-733 Mesylate
- BMS 201038 Mesylate
- BMS201038 Mesylate
- BMS-201038 Mesylate
- N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate
- N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate
- BMS201038/LoMitapide Mesylate
- BMS 201038-04 USP/EP/BP
- Inhibitor,Lomitapide,Lomitapide Mesylate,AEGR-733,inhibit,AEGR 733,BMS-201038,AEGR733,BMS201038,BMS 201038
- N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate[AEGR-733 Mesylate
- N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate
- N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate
- ロミタピドメシル酸塩
- ロミタピドメシル酸塩 (JAN)
- メシル酸ロミタピド
- ジャクスタピッド
- N-(2,2,2-トリフルオロエチル)-9-[4-[4-[[4′-(トリフルオロメチル)-1,1′-ビフェニル-2-イル]カルボニルアミノ]ピペリジン-1-イル]ブチル]-9H-フルオレン-9-カルボアミド・メタンスルホン酸