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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

化学構造式
289472-81-7
CAS番号.
289472-81-7
化学名:
别名:
英語名:
N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
英語别名:
Bortezomib EP IMP M;Bortezomib USP IMP J;Bortezomib Impurity D;Bortezomib Impurity J;Bortezomib Impurity 48;Bortezomib USP Impurity J;BortezomibHydroxy(1S,2S)-Isomer;Bortezomib USP Related Compoud J;(S)-Hydroxy Des(boric Acid) BortezoMib;(S,S)-Bortezomib Hydroxyisopentyl Amide Analog
CBNumber:
CB02661665
化学式:
C19H24N4O3
分子量:
356.42
MOL File:
289472-81-7.mol

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide 物理性質

沸点 :
672.0±55.0 °C(Predicted)
比重(密度) :
1.199±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
Chloroform (Slightly), Methanol (Slightly)
酸解離定数(Pka):
11.90±0.46(Predicted)
外見 :
Solid
色:
White to Off-White

安全性情報

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCH935905
(S)-Hydroxy Des(boric Acid) Bortezomib 		289472-81-7 0.5mg ￥73500 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCH935905
(S)-Hydroxy Des(boric Acid) Bortezomib 		289472-81-7 5mg ￥558000 2024-03-01 購入

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide 化学特性,用途語,生産方法

使用

(S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide 上流と下流の製品情報

原材料

準備製品

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide 生産企業

Global( 69)Suppliers
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289472-81-7()キーワード:

1-ブロモ-2-メチルプロパン 2,3-ピラジンジカルボン酸 1-クロロ-2-メチルプロパン N-(tert-ブトキシカルボニル)-D-フェニルアラニン N-[(1S)-2-アミノ-2-オキソ-1-(フェニルメチル)エチル]-2-ピラジンカルボキサミド イソブチルボロン酸 2-メチルプロパンボロン酸(1S,2S,3R,5S)-(+)-2,3-ピナンジオールエステル N-(ピラジニルカルボニル)-L-フェニルアラニン
  • 289472-81-7
  • 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
  • (S)-Hydroxy Des(boric Acid) BortezoMib
  • (N-[(1S)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide
  • Bortezomib Impurity 48
  • Bortezomib Impurity J
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
  • Bortezomib USP IMP J
  • Bortezomib Impurity D
  • Bortezomib USP Related Compoud J
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-Pyrazinecarboxamide
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-pyrazi
  • Bortezomib USP Impurity J
  • Bortezomib Related Compund J/ (S,S)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,S-Isomer Impurity)
  • BortezomibHydroxy(1S,2S)-Isomer
  • (S,S)-Bortezomib Hydroxyisopentyl Amide Analog
  • Bortezomib EP IMP M
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylprop
  • N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenyl
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