(±)-フェンフルラミン塩酸塩標準品

(±)-フェンフルラミン塩酸塩標準品 化学特性,用途語,生産方法

効能

食欲抑制薬

化学的特性

Crystalline Solid

使用

Controlled substance. Anorexic

定義

ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

一般的な説明

Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT_1B and the 5-HT_2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.

安全性プロファイル

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl

(±)-フェンフルラミン塩酸塩標準品 上流と下流の製品情報

原材料

準備製品

404-82-0((±)-フェンフルラミン塩酸塩標準品)キーワード:

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• 404-82-0
• FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD)
• N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride
• (+)-n-ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride
• BenzeneethanaMine,N-ethyl-a-Methyl-3-(trifluoroMethyl)-,hydrochloride (1:1)
• (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine
• n-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
• N-ETHYL-ALPHA-METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
• N-ETHYL-ALPHA-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
• N-Ethyl-α-methyl-3-[trifluoromethyl] benzeneethanamine hydrochloride
• rac Fenfluramine Hydrochloride
• 1-(3-trifluoromethylphenyl)-2-ethylaminopropanehydrochloride
• n-ethyl-alpha-methyl-m-(trifluoromethyl)-phenethylaminhydrochloride
• phenfluoraminehydrochloride
• ponderal
• ponderax
• (+/-)-FENFLURAMINE HYDROCHLORIDE
• FENFLURAMINE HYDROCHLORIDE
• FEBFLURAMINE HYDROCHLORIDE
• FENFLURAMINE (UNLABELED) 1.0 MG/ML IN METHANOL
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• Fenfluramine hydrochloride USP/EP/BP
• FENFLURAMINE HCL
• 2H6]-Fenfluramine hydrochloride
• 3-trifluoromethyl-N-Ethylamphetamine (hydrochloride) (exempt preparation)
• (±)-フェンフルラミン塩酸塩標準品
• 塩酸フェンフルラミン
• フェンフルラミン塩酸塩
• N-エチル-α-メチル-3-(トリフルオロメチル)ベンゼンエタンアミン・塩酸塩
• フェンフルラミン・塩酸塩