BPV(PIC)
BPV(PIC) 物理性質
- 貯蔵温度 :
- -20°C
- 溶解性:
- H2O: 可溶20mg/mL、透明
- 外見 :
- 粉
- 色:
- 淡い黄色から濃い黄色
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML0885 |
≥95% V basis
bpV(pic) ≥95% V basis |
148556-27-8 |
5mg |
￥17200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0885 |
≥95% V basis
bpV(pic) ≥95% V basis |
148556-27-8 |
25mg |
￥56100 |
2024-03-01 |
購入 |
BPV(PIC) 化学特性,用途語,生産方法
使用
bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM). bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes.
Biochem/physiol Actions
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
BPV(PIC) 上流と下流の製品情報
原材料
準備製品
BPV(PIC) 生産企業
Global( 49)Suppliers
- 148556-27-8
- DIPOTASSIUM BISPEROXO(PICOLINATO)OXOVANADATE (V)
- BPV(PIC)
- Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate
- Dipotassium Bisperoxovanadium(pic) dihydrate
- K2 [VO(O2)2C6H4NO2] 2 H2O
- bpV(pic) (potassium hydrate)