オリバシン 化学特性,用途語,生産方法
解説
1,5-dimethyl-6H-pyrido[4.3-b]carbazole.C17H14N2(246.31).オリバシン, キョウチクトウ科Aspidosperma olivaceum,A.longepetiolatum,A.australeなどに含まれるインドールアルカロイドの一つ.黄色の柱状晶.融点317~325 ℃(分解).希アルコール溶液は蛍光を発する.λmax 224,238,276,287,292,314,329,375 nm(log ε 4.39,4.33,4.70,4.85,4.83,3.66,3.80,3.66.エタノール).pKa 7.91±0.40.メタノール,アセトン,クロロホルムに可溶,水に難溶.森北出版「化学辞典(第2版)
説明
This alkaloid has recently been shown to exhibit a marked antineoplastic activity.
Administration of 25 or 50 mg/kg intraperitoneally on alternate days or daily until
death to mice which had been inoculated with a single intraperitoneal dose of
106 -102 LI2l0 leukemia cells increased the survival time by 89-229 per cent
compared with control animals.
Japanese workers have recently reported the synthesis of olivacine by heating
indole with 4(1-hydroxyethyl)-3-methoxymethyl-2-methylpyridine in 47 per
cent HBr.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 27, p. 1751, 1990
DOI: 10.1002/jhet.5570270645
参考文献
Regina et al., Cienc. Cult. (Sao Paulo), 26, 517 (1974)
Synthesis:
Kametani et al., J. Chern. Soc., Perkin I, 2102 (1975)
オリバシン 上流と下流の製品情報
原材料
準備製品