TOPO I HUMAN 化学特性,用途語,生産方法
使用
Topoisomerase I human has been used for Topoisomerase I assay for screening inhibitors.
一般的な説明
Topoisomerase I (TOP1) is mapped to human chromosome 20q12. TOP1 is a 91 kDa type IB enzyme and consists of N-terminal highly charged domain, a core, linker domain and a C-terminal catalytic domain with Tyr-723 active site residue.
Biochem/physiol Actions
Topoisomerase I human (TOP1) interacts with DNA by wrapping and takes a bi-lobed conformation. TOPI is essential for normal development and transcriptional regulation. Variants in the TOP1 gene is observed in patients with colorectal cancer.
TOPO I HUMAN 上流と下流の製品情報
原材料
準備製品