パルミチン酸イソプロピル 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
定義
本品は、パルミチン酸(*)とイソプロパノール(*)とのエステルであり、次の化学式で表される。
参照表示名称：パルミチン酸, イソプロパノール
溶解性
エタノール及びアセトンに溶け、水にほとんど溶けない。
解説
パルミチン酸イソプロピル，有機合成原料，化粧品，ペンキ，グリースなどに，ナトリウム塩はセッケンに使われるが，とくに融点が低く溶解性のよいことが要求される場合に用いられる。イソプロピルパルミテートは化粧品のクリーム類の主材料とされる。
用途
トリートメント / コンディショナー,クレンジング,化粧水 / 乳液 / クリーム,ファンデーション / 下地
原料由来
石油系および混合系エステル
化粧品の成分用途
エモリエント剤、結合剤、香料
効能
油脂性賦形剤
特徴
軽くさっぱりとした使用感の低粘性の油剤。
化学的特性
Isopropyl palmitate is a clear, colorless to pale yellow-colored,
practically odorless viscous liquid that solidifies at less than 16°C.
使用
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.
定義
ChEBI: Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a fatty acid ester and an isopropyl ester. It is functionally related to a hexadecanoic acid.
調製方法
Isopropyl palmitate is prepared by the reaction of palmitic acid with
propan-2-ol in the presence of an acid catalyst. A high-purity
material is also commercially available, which is produced by
enzymatic esterification at low temperatures.
一般的な説明
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in
Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
応用例（製薬）
Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate
副作用
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.
Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided.
安全性
Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
貯蔵
Isopropyl palmitate is resistant to oxidation and hydrolysis, and
does not become rancid. It should be stored in a well-closed
container, above 16°C, and protected from light.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (topical and
transdermal preparations). Used in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
パルミチン酸イソプロピル 上流と下流の製品情報
原材料
準備製品