InSolution MG-132 in EtOH, ≥95% by HPLC - Calbiochem 化学特性,用途語,生産方法
一般的な説明
Potent, reversible, and cell-permeable proteasome inhibitor (K
i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC
50 = 3 μM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No.
474791) and the solid form of this compound (Cat. No.
474787) are also available.
Biochem/physiol Actions
Cell permeable: yes
InSolution MG-132 in EtOH, ≥95% by HPLC - Calbiochem 上流と下流の製品情報
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準備製品