モルヒネ 化学特性,用途語,生産方法
解説
モルヒネ，白色針状または柱状晶．110 ℃ で水和水を失い，230 ℃ で分解し，紫色となる．d420"1.32．pKa 6.13．アルカリ水に易溶，熱メタノールに可溶，水に難溶．[α]D20"－132°(メタノール)．λmax 285 nm(水)．酸化を受けやすく，また光によって褐色となる．塩酸塩(塩酸モルヒネ)は，皮下注射後数分で作用が現れ，半時間で極点に達し，数時間後に衰え，約半日後に消失する．このような鎮痛作用と同時に，不快感を忘れさせ，恍惚(こうこつ)感を起こさせるので，習慣性，耽溺(たんでき)性があり，麻薬に指定されている．
森北出版「化学辞典（第2版）
用途
医療においては癌性疼痛をはじめ、各種の疾病および外傷による疼痛を緩和する目的で使用される。薬剤の剤形としては錠剤、散剤、液剤、坐剤、注射剤があり、それぞれ実情に応じて使用される。「モルフィン」「モヒ」とも言う。
製法
モルヒネ，ケシ科Papaver somniferumの未熟果中に含まれる．アヘンの主アルカロイドで，約10％ 以上含有される．強力な麻酔鎮痛作用を有し，その名称はギリシア神話の眠りの神Morpheusに由来する．通常，一水和物で得られる．
効能
麻薬性鎮痛薬, オピオイド受容体作動薬
毒性
LD50 500 mg/kg(マウス，皮下)．
説明
Morphine is the principal alkaloid obtained from opium. Opium is the resinous latex that
exudes from the seed pod of the opium poppy, Papver somneferum, when it is lacerated.
Alkaloids account for approximately 25% of opium, and of this 25% about 60% is morphine.
化学的特性
White, crystalline alkaloid. Slightly soluble in water,alcohol, and ether.
物理的性質
Appearance: white or almost white crystalline powder or colorless, silky needles or
cubical masses, efflorescent in a dry atmosphere. Solubility: soluble in water,
slightly soluble in ethanol, practically insoluble in chloroform or ether. Specific
optical rotation: ?110.0° to 115.0°
来歴
Morphine has a strong analgesic effect, especially for moderate and severe cancer pain. However, morphine has serious side effects, such as addiction, respiratory depression, acute poisoning, and death. Therefore, in regulating the clinical application of morphine at the same time, it is necessary to explore the alternative to morphine with strong analgesic role and minor side effects.
In the 1970s, tramadol was launched and marketed as “Tramal” by the German pharmaceutical company Grünenthal GmbH in West Germany , and 20 years later, it was launched in countries such as the United Kingdom, the United States, and Australia. It is marketed in many brand names worldwide. After R&D of more than 100 years, opioid drugs were increased and have been widely used in clinic as analgesic drugs.
使用
A degradation product of Morphine. A dimolecular base formed by the gentle oxidation of Morphine in alkaline solution. Name Pseudomorphine is also used for the C17 alkaloid base
定義
ChEBI: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependen
e developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
調製方法
Morphine is detoxified or biotransformed mainly in the liver by conjugation with glucuronic acid. Morphine is conjugated by a series of reactions involving the formation of uridine diphosphoglucose (UDP-glucose), the oxidation of carbon-6 of glucose to form uridine diphosphoglucuronic acid (UDP-glucuronic acid) and the transfer of glucuronic acid to morphine to form the morphine glucuronide. The following enzymes catalyze the sequential reactions; reaction(1), UDP-glucose pyrophosphorylase; reaction (2), UDP-glucose dehydrogenase; reaction (3), glucuronyl transferase; reaction (4) nucleoside diphosphokinase.
適応症
Morphine is mainly used to treat both acute and chronic severe pain. It is also used
for pain caused by myocardial infarction and for labor pains. Morphine relieves
pulmonary edema symptoms; anesthesia and preoperative administration can make
the patient quiet and drowsy; compound formula of morphine was used for acute
and chronic diarrhea.
獲得抵抗性
It is important to remember that a minor change in the structure of morphine (or any other opioid)
will likely cause a different change in the affinity and intrinsic activity of the new compound at each
of the opioid receptor types. Thus, the opioid receptor selectivity profile of the new compound may
be different than the structure from which it was made or modeled (i.e., a selective μ agonist may
shift to become a selective κ agonist, etc.). In addition, the new compound will have different
physicochemical properties than its parent. The different physicochemical properties (e.g.,
solubility, partition coefficient, and pKa) will result in different pharmacokinetic characteristics for the new drug and
can affect its in vivo activity profile. For example, a new drug (Drug A) that is more lipophilic than
its parent may distribute better to the brain and appear to be more active, whereas in actuality, it
may have lower affinity or intrinsic activity for the receptor. The greater concentration of Drug A
reaching the brain is able to overcome its decreased agonist effect at the receptor.
危険性
Narcotic, habit-forming drug, salerestricted by law in the U.S.
接触アレルゲン
Morphine bitartrate caused contact dermatitis in a
worker at a plant producing opium alkaloids. Morphine
hydrochloride and morphine bitartrate showed patchtest-
positive reactions in another patient with contact
dermatitis working in the production of concentrated
poppy straw. We observed a concomitant reaction
between a morphine base and a codeine base in a
patient with drug skin eruption due to codeine.
薬物動態学
Morphine is the prototype opioid. It is selective for μ opioid receptors. The structure of
morphine is composed of five fused rings, and the molecule has five chiral centers with absolute
stereochemistry 5(R), 6(S), 9(R), 13(S) and 14(R). The naturally occurring isomer of morphine is
levo-[(–)] rotatory. (+)-Morphine has been synthesized, and it is devoid of analgesic and other
opioid activities.
安全性プロファイル
Poison experimentally
by ingestion, intracerebral, intraperitoneal,
subcutaneous, and intravenous routes.
Human reproductive effects by an
unspecified route: effects on newborn,
including drug dependence. Experimental
reproductive effects. Mutation data
reported.
Morphine is the constituent of opium most responsible for its toxic effects. When
taken orally, the effects of morphine
poisoning begin to appear in 20-40 minutes;
if taken hypodermically, the symptoms
appear much earlier and narcotism is more
likely to follow the early symptoms. Abuse
leads to habituation or adlction. Inlvidual
susceptibility varies greatly and children are
more susceptible than adults. When heated
to decomposition it emits toxic fumes of
NOx.
純化方法
Crystallise the narcotic from MeOH or anisole. It dehydrates at 130o. Its solubility in H2O is 0.2g/L at 20o and 0.9g/L at 100o, and in EtOH it is 5g/L at 20o and 10g/L on boiling. The styphnate has m 189o (from aqueous EtOH). [Beilstein 27 II 118, 27 III/IV 2223.]
参考文献
Derosne., Ann. Chirn., 45, 257 (1803)
Laurent., Ann. Chirn. Phys., 19, iii, 359 (1847)
Muller., Apoth. Zeit., 18, 257 (1903)
Mannich., Chern. Zentr., II, 820 (1916)
Emde., Helv. Chirn. Acta, 13, 1035 (1930)
Gates, Tschudi., 1. Arner. Chern. Soc., 78, 1380 (1956)
Crystal structure:
MacKay, Hodgkin., 1. Chern. Soc., 3261 (1955)
Synthesis:
Gates, TschudL,J. Arner. Chern. Soc., 74, 1109 (1952)
Elad, Ginsburg., ibid, 76,312 (1954)
Elad, Ginsburg., J. Chern. Soc., 3052 (1954)
Morrison, Waite, Shavel., Tetrahedron Lett., 4055 (1967)
NMR and mass spectra:
Rull., Bull. Soc. Chim. Fr., 586 (1963)
Okuda et al., Chern. Pharrn. Bull. (Tokyo), 11, 1465 (1963)
Wheeler, Kinstle, Rinehart., J. Arner. Chern. Soc., 89,4494 (1967)
Biosynthesis:
Barton et aI., J. Chern. Soc., 2423 (1965)
Pharmacology:
Vahlen., Arch. expo Path. Pharrn., 47, 368 (1902)
Small et al., Public Health Reports, Suppl. 138, Washington (1938)
Krueger, Eddy, Sumwalt., ibid, No. 165, Washington (1943)
モルヒネ 上流と下流の製品情報
原材料
準備製品