抗Β-チューブリンIII抗体 ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-β-Tubulin III antibody produced in rabbit has been used in following studies:
- Immunofluorescence
- Immunostaining
- Western blotting
一般的な説明
Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have several different isotypes . β-Tubulin III is a marker for nerve cell differentiation, as well as for venous and lymphatic valves . Changes in β-tubulin III expression have been associated with medulloblastoma
Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Anti-β-Tubulin III antibody is specific for β-Tubulin III in humans.
Biochem/physiol Actions
Tubulin β 3 class III (TUBB3) plays a vital role in nervous system development and axon guidance. Mutation of the gene encoding protein leads to the ocular motility disorder, congenital fibrosis of the extraocular muscle type 3 (CFEOM3), and various neurological syndromes. Altered expression of the protein affects microtubule dynamics and microtubule-kinesin interactions. Increased expression of TUBB3 is observed in tumor tissues. Decreased expression of TUBB3 can be considered as an important marker for poor prognosis of cutaneous malignant melanoma. TUBB3 is implicated in the suppression of invasive growth of tumor tissue;therefore, it is considered to be a potential target for development of antitumor drugs.
抗Β-チューブリンIII抗体 ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品