BEC
BEC 物理性質
- 沸点 :
- 451.6±55.0 °C(Predicted)
- 比重(密度) :
- 1.372±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- PBS (pH 7.2): 5 mg/ml
- 外見 :
- 粉
- 酸解離定数(Pka):
- 2.10±0.10(Predicted)
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10170 |
BEC |
63107-40-4 |
1mg |
￥10400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10170 |
BEC |
63107-40-4 |
5mg |
￥45100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1384 |
≥98% (HPLC)
BEC hydrochloride ≥98% (HPLC) |
63107-40-4 |
5mg |
￥27000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1384 |
≥98% (HPLC)
BEC hydrochloride ≥98% (HPLC) |
63107-40-4 |
25mg |
￥106000 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10170 |
BEC |
63107-40-4 |
10mg |
￥79200 |
2024-03-01 |
購入 |
BEC 化学特性,用途語,生産方法
使用
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 μM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.
Biochem/physiol Actions
BEC (S-(2-boronoethyl)-l-cysteine) is a potent and specific arginase inhibitor that restores flow-induced responses in arterioles from diabetic rats.
酵素阻害剤
This boronic acid-containing arginine analogue (FW = 190.00 g/mol; CAS 63107-40-4; Abbreviation: BEC) is a slow, tight-binding competitive inhibitor of arginase (Reaction: L-Arginine + H2O ? Urea + L-Ornithine), the binuclear manganese metalloenzyme catalyzing the last step in the Urea Cycle. Upon binding, the boronic acid moiety undergoes nucleophilic attack by the enzyme’s metal-bridging hydroxide ion, yielding a tetrahedral boronate anion that bridges the binuclear manganese cluster and mimics the tetrahedral intermediate (or a flanking transition state configuration) in arginase catalysis. BEC is also a potent inhibitor of human arginase II with Ki values of 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively. Inhibition of arginase by BEC increases the circulating concentration of arginine, thereby increasing nitric oxide synthesis and significantly enhancing NO-dependent smooth muscle relaxation in human penile corpus cavernosum. Arginase is thus a potential druggable target for the treatment of erectile dysfunction.
BEC 上流と下流の製品情報
原材料
準備製品
BEC 生産企業
Global( 50)Suppliers
63107-40-4()キーワード:
- 63107-40-4
- BEC
- S-(2-BORONOETHYL)-L-CYSTEINE
- L-Cysteine, S-(2-boronoethyl)-
- (2S)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid
- Arginase II（BEC hydrochloride）