2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル
2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル 物理性質
- 融点 :
- 158-160°C
- 沸点 :
- 495.9±55.0 °C(Predicted)
- 比重(密度) :
- 1.183
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 溶解性:
- クロロホルム（わずかに）、メタノール（わずかに、超音波処理）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 1.39±0.10(Predicted)
- 色:
- ペールイエロー
- InChI:
- InChI=1S/C18H21NO4S/c1-5-22-18(21)16-12(4)19-17(24-16)13-6-7-15(14(8-13)9-20)23-10-11(2)3/h6-9,11H,5,10H2,1-4H3
- InChIKey:
- AIQMFFCWDAIGNV-UHFFFAOYSA-N
- SMILES:
- S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C=O)=C1
- CAS データベース:
- 161798-03-4(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル 価格
もっと(6)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-1325 |
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
161798-03-4 |
1g |
￥32500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-1325 |
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
161798-03-4 |
5g |
￥87500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-1325 |
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
161798-03-4 |
10g |
￥162500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC213581 |
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
161798-03-4 |
1g |
￥30000 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC213581 |
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
161798-03-4 |
5g |
￥80000 |
2021-03-23 |
購入 |
2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル 化学特性,用途語,生産方法
使用
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.
合成
Preparation of Compound of formula III)[0094] A compound of formula II (10.0 gr, 34.33 mmol) was reacted with iso- butyl bromide (18.9 gr, 137.3 mmol) in the presence of potassium carbonate (19.0 gr, 137.3 mmol) and potassium iodide (2.3 gr, 13.7 mmol) in 60 ml dimethylformamide. The reaction was performed at about 70°C during 4 hours. The reaction mixture was extracted at 70°C using 300 ml ethyl acetate and 600 ml water. The separated aqueous phase was washed twice with 100 ml ethyl acetate. The combined organic phase was washed twice with 100 ml water and then concentrated to dryness. The resulting solid residue was re- crystallized from 70 ml ethyl acetate, filtered and dried under reduced pressure at about 40°C to provide a compound of formula III (8.9 gr, yield - 83percent). The Compound of formula III purity is 99.1percent (by HPLC).
2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル 上流と下流の製品情報
原材料
準備製品
2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル 生産企業
Global( 329)Suppliers
161798-03-4(2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル)キーワード:
- 161798-03-4
- 2-(3-forMyl
- 5-Thiazolecarboxylicacid, 2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester
- ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylate
- Febuxostat Impurity 2
- Febuxostat Impurity G
- 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
- Ethyl 2-(3-formyl-4-isobutoxyphenyl)
- ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
- 2-(3-Formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester
- 5-carboxylato-1-ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
- 2-(3-forMyl-4-isobutoxyphenyI)-4-MethyIthiazole-5-carboxylic acid ethyl ester
- Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-
- Ethyl-2-(3-Formyl-4-isobutoxy phenyl)-4-methyl-1,3-thiazole-5-carboxylate
- Febuxostat-24
- Febuxostat Impurity Z18
- Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz
- 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylicacid ethyl ester
- -4-isobutoxyphenyL
- Febuxostat intermediates，Ethyl 2-(3-Formyl-4-isobutoxyphenyl)- 4-Methylthiazole-5-Carboxylate
- Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-
- Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carb...
- Febuxostat Impurities2
- 2 - (3-aldehyde-4-isobutyloxyphenyl) - 4-methylthiazole-5-carboxylic acid ethyl ester
- Ethyl 2-(3- aldehyde -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate
- 5-Thiazolecarboxylic acid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester (9CI, ACI)
- 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI)
- Febuxostat Impurity Z2-2
- Febuxostat Impurity 2
ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate
- Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate (F4)
- 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat
- 2-(3-ホルミル-4-イソブトキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル
- エチル 2-[3-ホルミル-4-(2-メチルプロポキシ)フェニル]-4-メチル-1,3-チアゾール-5-カルボキシラート
- 2-(3-ホルミル-4-イソブトキシフェニル)-4-メチル-1,3-チアゾール-5-カルボン酸エチル