3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
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- CAS番号.
- 350997-39-6
- 化学名:
- 别名:
- 英語名:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- 英語别名:
- OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- CBNumber:
- CB11499417
- 化学式:
- C9H6Cl2N2OS
- 分子量:
- 261.13
- MOL File:
- 350997-39-6.mol
- MSDS File:
- SDS
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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 物理性質
- 比重(密度) :
- 1.587±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 11.75±0.30(Predicted)
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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SML1697 |
≥98% (HPLC)
OGG1 Inhibitor O8 ≥98% (HPLC) |
350997-39-6 |
5mg |
￥21800 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
|
SML1697 |
≥98% (HPLC)
OGG1 Inhibitor O8 ≥98% (HPLC) |
350997-39-6 |
25mg |
￥69900 |
2024-03-01 |
購入 |
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 化学特性,用途語,生産方法
使用
O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
一般的な説明
Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Biochem/physiol Actions
OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 上流と下流の製品情報
原材料
準備製品
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 生産企業
Global( 40)Suppliers
350997-39-6()キーワード:
- 350997-39-6
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- OGG1 Inhibitor O8
- O8 OGG1 Inhibitor
- 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
- OGG1-IN-O8
- OGG1 Inhibitor O8 >=98% (HPLC)
- OGG1-IN-08
- Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide