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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

化学構造式
388575-52-8
CAS番号.
388575-52-8
化学名:
别名:
英語名:
4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride
英語别名:
PSN375963;PSN 375963 hydrochloride;5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole;4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine;Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-;4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride;Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP
CBNumber:
CB12518900
化学式:
C17H23N3O
分子量:
285.38
MOL File:
388575-52-8.mol

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride 物理性質

沸点 :
440.1±47.0 °C(Predicted)
比重(密度) :
1.060±0.06 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMSO：>10mg/mL
酸解離定数(Pka):
0.82±0.10(Predicted)
外見 :
粉
色:
ホワイトからオフホワイト

安全性情報

WGK Germany  nwg

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3353
PSN 375963 hydrochloride 		388575-52-8 10mg ￥50000 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01TOC3353
PSN 375963 hydrochloride 		388575-52-8 50mg ￥217000 2020-09-21 購入
Sigma-Aldrich Japan P0028 ≥98% (HPLC)
PSN-375963 ≥98% (HPLC)		 388575-52-8 5mg ￥13700 2021-03-23 購入
Sigma-Aldrich Japan P0028 ≥98% (HPLC)
PSN-375963 ≥98% (HPLC)		 388575-52-8 25mg ￥42080 2021-03-23 購入

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride 化学特性,用途語,生産方法

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride 上流と下流の製品情報

原材料

準備製品

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride 生産企業

Global( 42)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
 sales@meilune.com China 4664 58
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2384 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
Angel Pharmatech, Ltd. 17317130613
 3358272972@qq.com China 3246 58
BOC Sciences --
 info@bocsci.com USA 0 65

  スペクトルデータ(1HNMR)

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride(388575-52-8)1HNMR
  • 388575-52-8
  • 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride
  • PSN 375963 hydrochloride
  • PSN375963
  • 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
  • 5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole
  • Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP
  • Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-
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