DWK-1339
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- CAS番号.
- 1018946-38-7
- 化学名:
- 别名:
- 英語名:
- DWK-1339
- 英語别名:
- SNU-0039;DWK-1339;SNU-0039 (DWK-133);DWK-1339;DWK 1339;DWK1339;2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran;Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-;2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran;MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339
- CBNumber:
- CB12627783
- 化学式:
- C20H22O4
- 分子量:
- 326.39
- MOL File:
- 1018946-38-7.mol
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DWK-1339 物理性質
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 2mg/mL
- 外見 :
- A crystalline solid
- 色:
- White to off-white
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
DWK-1339 価格
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製品番号 |
製品説明 |
CAS番号 |
包装 |
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更新時間 |
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DWK-1339 化学特性,用途語,生産方法
説明
DWK-1339 is an inhibitor of amyloid-β (Aβ) aggregation. It inhibits aggregation of monomeric Aβ (1-42) (Aβ42) and induces disaggregation of Aβ42 fibrils
in vitro when used at concentrations ranging from 3.1 to 50 μM. DWK-1339 (10 μM) reduces Aβ42-induced toxicity in HT-22 cells.
In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Aβ42-induced acute Alzheimer''s disease. It also decreases brain levels of Aβ42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer''s disease.
使用
DWK-1339, is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer''s disease.
DWK-1339 上流と下流の製品情報
原材料
準備製品
DWK-1339 生産企業
Global( 33)Suppliers
- 1018946-38-7
- DWK-1339
- 2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran
- Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-
- 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran
- DWK-1339;DWK 1339;DWK1339
- SNU-0039
- SNU-0039 (DWK-133)
- MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339