テネリグリプチン臭化水素酸塩水和物
テネリグリプチン臭化水素酸塩水和物 物理性質
- 融点 :
- >211°C (dec.)
- 貯蔵温度 :
- Refrigerator
- 溶解性:
- メタノール(わずかに)
- 外見 :
- 個体
- 色:
- ホワイトからライトベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
|
注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H413 |
長期的影響により水生生物に有害のおそれ |
水生環境有害性、慢性毒性 |
4 |
|
|
|
|
注意書き |
P273 |
環境への放出を避けること。 |
P501 |
内容物/容器を...に廃棄すること。 |
|
テネリグリプチン臭化水素酸塩水和物 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
テネリグリプチン臭化水素酸塩水和物 化学特性,用途語,生産方法
効能
糖尿病治療薬, DPP-4阻害薬
商品名
テネリア (田辺三菱製薬)
使用
Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
臨床応用
Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II
diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name
Tenelia®. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and
QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1
levels, with very low rates of renal excretion.
合成
The only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially
available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide
160 in 86% yield, and this material was immediately condensed with phenylhydrazine in
methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161
in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162
in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans-
4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming
conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid.
This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield.
Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield,
and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give
teleligliptin hydrobromide hydrate (XXV) in 90% yield.
テネリグリプチン臭化水素酸塩水和物 上流と下流の製品情報
原材料
準備製品
テネリグリプチン臭化水素酸塩水和物 生産企業
Global( 177)Suppliers
テネリグリプチン臭化水素酸塩水和物 スペクトルデータ(MS)
906093-29-6(テネリグリプチン臭化水素酸塩水和物)キーワード:
- 906093-29-6
- Teneligliptin (hydrobroMide)
- Teneligliptin HydrobroMide (2:5)
- MP-513 (hydrobromide)
- Teneligliptin hydrobromide anhydrous
- TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE
- ((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone
- 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piper...
- Teneligliptin hydrobromideQ: What is
Teneligliptin hydrobromide Q: What is the CAS Number of
Teneligliptin hydrobromide Q: What is the storage condition of
Teneligliptin hydrobromide Q: What are the applications of
Teneligliptin hydrobromide
- Teneligliptin Hydrobromide API
- Teneligliptin HydrobroMide Hydrate
- 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)
- Teneligliptin HBr
- [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide
- API(Teneligliptin hydro bromide hydrate)
- 3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O
- Teneligliptin(hydrobromide)-amorphous
- Bis(((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone) pentahydrobromide
- Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-, hydrobromide (2:5)
- (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-Methanone hydrobromide (2:5)
- Ticagrelor hydrobromide
- Teneligliptin HBr
[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]- 2-pyrrolidinyl]-3-thiazolidinylmethanone HBr
- Tepagliptin (Hydrobromide)
- テネリグリプチン臭化水素酸塩水和物 (JAN)
- テネリグリプチン臭化水素酸塩