SF1670(PTENinhibitor)
SF1670(PTENinhibitor) 物理性質
- 沸点 :
- 554.1±29.0 °C(Predicted)
- 比重(密度) :
- 1.271±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO:可溶10mg/mL、透明
- 外見 :
- 赤紫固体
- 酸解離定数(Pka):
- 14.31±0.20(Predicted)
- 色:
- 、薄ピンクから赤、そして非常に濃い紫
SF1670(PTENinhibitor) 価格
もっと(4)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5020 |
SF 1670 |
345630-40-2 |
10mg |
¥56000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5020 |
SF 1670 |
345630-40-2 |
50mg |
¥235000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML0684 |
≥98% (HPLC)
SF1670 ≥98% (HPLC) |
345630-40-2 |
5mg |
¥46500 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML0684 |
≥98% (HPLC)
SF1670 ≥98% (HPLC) |
345630-40-2 |
25mg |
¥148000 |
2021-03-23 |
購入 |
SF1670(PTENinhibitor) 化学特性,用途語,生産方法
使用
SF1670 is used in the methods and compositions for treating tumor or cancer by administering to a subject a PTEN inhibitor and chemotherapeutic agents, immume dysregulation in patients with PTEN harmartoma tumor syndrome and analysis of FOXP3 regulatory T cells.
一般的な説明
A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC
50 = 200 nM using
pNPP as the substrate, 3.8 μM for CD45
lck, >30 μM for PTP1B
lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC
50 = 100 nM). Shown to be less cytotoxic (CC
50 = 3.5 μM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
Biochem/physiol Actions
Cell permeable: yes
SF1670(PTENinhibitor) 上流と下流の製品情報
原材料
準備製品
SF1670(PTENinhibitor) 生産企業
Global( 101)Suppliers
345630-40-2()キーワード:
- 345630-40-2
- SF1670(PTENinhibitor)
- N-(9,10-Dioxo-9,10-dihydro-2-phenanthrenyl)-2,2-diMethylpropanaMide
- PTP CD45 Inhibitor
- 6-PHENYL-2-(2-PYRAZINYL)-4(1H)-PYRIMIDINONE
- SF1670
- N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
- PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem
- SF 1670;SF-1670
- CS-1143
- Propanamide, N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-
- SF1670 >=98% (HPLC)