1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 物理性質
- 貯蔵温度 :
- Inert atmosphere,Room Temperature
- CAS データベース:
- 1628047-87-9
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 価格
もっと(7)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC504674 |
1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE DIHYDROCHLORIDE |
1628047-87-9 |
5g |
¥25000 |
2021-03-23 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC504674 |
1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE DIHYDROCHLORIDE |
1628047-87-9 |
10g |
¥40600 |
2021-03-23 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC504674 |
1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE DIHYDROCHLORIDE |
1628047-87-9 |
25g |
¥75600 |
2021-03-23 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC497243 |
1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride |
1628047-87-9 |
5g |
¥26400 |
2020-09-21 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC497243 |
1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride |
1628047-87-9 |
1g |
¥8600 |
2018-12-26 |
購入 |
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 化学特性,用途語,生産方法
使用
1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
合成
To a solution of tert-butyl 4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1 -enyl)methyl)piperazine-1 - carboxylate 6 (30 g, 0.072 mol) in MeOH (20 mL) was added conc.HCI (50 mL). The reaction was stirred for 24 hours and then concentrated under reduced pressure. A saturated solution of NazCCh was added to adjust the pH to 8-9, and the mixture was extracted with dichloromethane (2x200 mL). The combined extracts were washed with brine, dried (NazSC ), filtered, and concentrated under reduced pressure. The oil product was treated with MeOH/HCI (g) (3.0 M, 500 mL) and stirred for 1 hour, then concentrated under reduced pressure to get the product 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride (23 g, 83%).
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 上流と下流の製品情報
原材料
準備製品
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 生産企業
Global( 180)Suppliers
1628047-87-9()キーワード:
- 1628047-87-9
- 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- ABT199 intermediate1
- abt199 int 1
- 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine dihydrochloride
- 1-((4'-chloro-5,5-demethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl-2yl]methyl)piperazine dihydrochloride
- 1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine dihydrochloride
- Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2)
- 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrah
ydro-[1,1'-biphenyl]-2-yl)methy)piperazine dihydrochloride
- 1-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}piperazine dihydrochloride
- 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]
methyl]-Piperazine, hydrochloride (1:2)
- 1-((4-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 2HCl
- 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydroch
- 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine hydrochloride
- 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine diHCL
- ABT-199 Intermeidate1
- Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]- (Dihydrochloride)
- Venetoclax Intermediate 2
- 1-[[2-(4-chlorophenyl)-4,4-dimethyl-cyclohexen-1-yl]methyl]piperazine dihydrochloride
- 1-((4-chloro-5
- 1-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- 5-dimethyl-3
- 1 - ((4 '- chloro-5,5-dimethyl-3,4,5,6-tetrahydro - [1,1' - diphenyl] - 2-yl) methyl) piperazine dihydrochloride
- Venetoclax Impurity 31(Hydrochloride)
- Venetoclax Impurity 23 DiHCl
- 1-((2-chlorophelyl)-4,4-diemethylcyclohex-1-en-1-yl)methyl)piperazine dihydrochloride
- 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-
yl]methyl]-piperazine,dihydrochlorid
- 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine dihydrochloride