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PFI-4

化学構造式
900305-37-5
CAS番号.
900305-37-5
化学名:
别名:
英語名:
PFI-4
英語别名:
PFI-4;CS-2035;PFI4;PFI 4;N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide;N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-2-methoxybenzamide;N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide;Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-;N-(1,3-dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide;
N-(1,3-Dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5 -yl)-2-methoxybenzamide;PFI 4,bone loss,Epigenetic Reader Domain,PFI-4,Inhibitor,inhibit,osteoclasts,osteolytic malignant bone lesions
CBNumber:
CB13041445
化学式:
C21H24N4O3
分子量:
380.44
MOL File:
900305-37-5.mol

PFI-4 物理性質

沸点 :
512.1±50.0 °C(Predicted)
比重(密度) :
1.291±0.06 g/cm3(Predicted)
貯蔵温度 :
room temp
溶解性:
insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥2.87 mg/mL in EtOH with gentle warming and ultrasonic
酸解離定数(Pka):
12.88±0.20(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

PFI-4 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC5576
PFI 4 		900305-37-5 10mg ￥62000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC5576
PFI 4 		900305-37-5 50mg ￥255000 2024-03-01 購入
Sigma-Aldrich Japan PZ0307 ≥98% (HPLC)
PFI-4 ≥98% (HPLC)		 900305-37-5 5mg ￥14400 2024-03-01 購入
Sigma-Aldrich Japan PZ0307 ≥98% (HPLC)
PFI-4 ≥98% (HPLC)		 900305-37-5 25mg ￥57700 2024-03-01 購入

PFI-4 化学特性,用途語,生産方法

使用

PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 inhibiting binding to tri-acetylated histone 4 affecting the development of multiple tissues axial skeleton and hematopoietic system.

Biochem/physiol Actions

PFI-4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. The BRPF proteins (BRPF1/2/3) assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. Mutations in MOZ, MORF, and BRPF1 have all been associated with cancer. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. For full characterization details, please visit the PFI-4 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

PFI-4 上流と下流の製品情報

原材料

準備製品

PFI-4 生産企業

Global( 71)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30253 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9991 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203
 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58

  スペクトルデータ(1HNMR)

PFI-4(900305-37-5)1HNMR
  • 900305-37-5
  • PFI-4

  • N-(1,3-Dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5 -yl)-2-methoxybenzamide
  • Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-
  • N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
  • PFI4;PFI 4
  • CS-2035
  • N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-2-methoxybenzamide
  • N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
  • N-(1,3-dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
  • PFI 4,bone loss,Epigenetic Reader Domain,PFI-4,Inhibitor,inhibit,osteoclasts,osteolytic malignant bone lesions
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