モノクローナル抗Τ(タウ)抗体 マウス宿主抗体 化学特性,用途語,生産方法
使用
Monoclonal Anti-τ (Tau) antibody has been used:
- in immunohistology
- in immunoblotting
- in dot blot
- in immunohistochemistry
一般的な説明
Monoclonal Anti- τ (TAU) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. τ (TAU) proteins are a part of microtubule associated proteins (MAPs). They are densely found in neurons and in trace amounts in non-neuronal cells. In brain six isoforms of τ (TAU) proteins are present.
Biochem/physiol Actions
Monoclonal Anti- τ (TAU) is phosphatase independent; it will bind Tau proteins in either their phosphorylated or non-phosphorylated forms. It localizes Tau proteins along microtubules in axons, somata, dendrites, astrocytes and on ribosomes (polysomes). The best-known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is immunologically distinct from the other MAPs. Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.
モノクローナル抗Τ(タウ)抗体 マウス宿主抗体 上流と下流の製品情報
原材料
準備製品