抗繊維芽細胞増殖因子レセプター3, 細胞外抗体 ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:
- immunoblotting
- immunohistochemistry
- immunoprecipitation
一般的な説明
FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.
Biochem/physiol Actions
Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.
抗繊維芽細胞増殖因子レセプター3, 細胞外抗体 ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品