Pomalidomide-PEG3-NH2 hydrochloride 化学特性,用途語,生産方法
使用
Protein degrader builiding block Pomalidomide-PEG
3-NH
2 (HCl salt) enables the synthesis of molecules for
targeted protein degradation and
PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.
When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG3-NH2 hydrochloride 上流と下流の製品情報
原材料
準備製品