[(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2

[(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2 価格 もっと(7)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01BCS4034722	[(2R,4R,5S)-2-ベンジル-5-(Boc-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-Leu-Phe-NH2 [(2R,4R,5S)-2-Benzyl-5-(Boc-amino)-4-hydroxy-6-phenyl-hexanoyl]-Leu-Phe-NH2	292632-98-5	1mg	￥68000	2020-09-21	購入
富士フイルム和光純薬株式会社(wako)	W01BCS4034722	[(2R,4R,5S)-2-ベンジル-5-(Boc-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-Leu-Phe-NH2 [(2R,4R,5S)-2-Benzyl-5-(Boc-amino)-4-hydroxy-6-phenyl-hexanoyl]-Leu-Phe-NH2	292632-98-5	5mg	￥323000	2020-09-21	購入
Sigma-Aldrich Japan	L1790	>96% (HPLC), solid L-685,458 >96% (HPLC), solid	292632-98-5	1mg	￥75400	2024-03-01	購入
Sigma-Aldrich Japan	L1790	>96% (HPLC), solid L-685,458 >96% (HPLC), solid	292632-98-5	5mg	￥314400	2021-03-23	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2627	L-685,458	292632-98-5	1mg	￥105000	2024-03-01	購入

[(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2 化学特性,用途語,生産方法

外観

白色〜わずかにうすい黄色, 結晶〜粉末又は塊

溶解性

DMSO　>10 mg/mL

使用

N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide, is a γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the major causative agent in Alzheimer disease (AD).

生物活性

Potent and selective γ -secretase inhibitor (IC 50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC 50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro .

Biochem/physiol Actions

L-685,458 mimics the transition state in aspartyl protease. It possesses an IC50 of 17nM with respect to inhibition of Aβ synthesis. It is known to block Notch (neurogenic locus notch homolog protein) signaling, which in turn reduces ERK (extracellular signal regulated kinase) phosphorylation by EGF (epidermal growth factor). L-685,458 targets the active site and substrate binding site of the enzyme.

[(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2 上流と下流の製品情報

原材料

準備製品

[(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Shanghai fuxiang biotechnology co., ltd	13611719524	2674347328@qq.com	China	59	58

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• 292632-98-5
• (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide
• N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide
• CS-2367
• L-685458 (L-685,458
• L-685458;L 685458;L685458
• L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-
• Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458
• L-685,458, gamma-secretase inhibitor
• L-685458, 10 mM in DMSO
• [(2R,4R,5S)-2-ベンジル-5-(BOC-アミノ)-4-ヒドロキシ-6-フェニル-ヘキサノイル]-LEU-PHE-NH2