anaplastic lymphoma kinase 化学特性,用途語,生産方法
説明
Anaplastic lymphoma kinase (ALK) fusion in non-small cell lung cancer (NSCLC)
was first described by Soda and colleagues in 2007. Using a retrovirus-mediated
complementary DNA expression system, they discovered that a small inversion in
the chromosome 2p results in a product consisting of portions of the echinoderm
microtubule-associated protein-like 4 (EML4) gene and the ALK gene. The fusion
had transforming properties in mouse 3T3 fibroblast model and was targetable by
ALK inhibitor WHI-P154 [1].
anaplastic lymphoma kinase 上流と下流の製品情報
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