Methylene boldenone
Methylene boldenone 物理性質
- 融点 :
- 134-136°C
- 比重(密度) :
- 1.14
- 貯蔵温度 :
- -20°C Freezer
- 溶解性:
- クロロホルム(微量)、メタノール(微量)
- 外見 :
- 個体
- 色:
- オフホワイト
- CAS データベース:
- 122370-91-6
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
Methylene boldenone 価格
もっと(2)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCH942340 |
17β-Hydroxy Exemestane |
122370-91-6 |
1mg |
¥60600 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCH942340 |
17β-Hydroxy Exemestane |
122370-91-6 |
10mg |
¥399900 |
2023-06-01 |
購入 |
Methylene boldenone 化学特性,用途語,生産方法
説明
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC
50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC
50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC
50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC
50 = 2.7 μM) and T47D breast cancer cells (EC
50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
化学的特性
Off-White Solid
使用
A metabolite of Exemestane; exerts biological effects as an androgen.
Methylene boldenone 上流と下流の製品情報
原材料
準備製品
Methylene boldenone 生産企業
Global( 59)Suppliers
122370-91-6()キーワード:
- 122370-91-6
- METHYLENE BOLDENONE
- (17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
- (17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
- 17--Hydroxy Exemestane
- (17β)-
- 17β-Hydroxy ExeMestane SulfaMate
- Exemestane 17β-Hydroxy Impurity
- Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
- 17β-Hydroxy Exemestane
- (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
- Exemestane Impurity 23 (Exemestane EP Impurity H)
- 17beta-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17beta-Hydroxyexemestane)