BMS493
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- CAS番号.
- 215030-90-3
- 化学名:
- BMS493
- 别名:
- BMS493;4-[2-[5,5-ジメチル-8-(フェニルエチニル)-5,6-ジヒドロナフタレン-2-イル]ビニル]安息香酸;4-{2-[5,5-ジメチル-8-(2-フェニルエチニル)-5,6-ジヒドロナフタレン-2-イル]エテニル}安息香酸
- 英語名:
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
- 英語别名:
- BMS 493;BMS204, 493;BMS493,BMS-493;(E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid;4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid;4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid;(E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid;Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-
- CBNumber:
- CB22518846
- 化学式:
- C29H24O2
- 分子量:
- 404.5
- MOL File:
- 215030-90-3.mol
- MSDS File:
- SDS
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BMS493 物理性質
- 沸点 :
- 605.4±55.0 °C(Predicted)
- 比重(密度) :
- 1.21±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：20mg/mL以上
- 酸解離定数(Pka):
- 4.27±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 薄黄色～黄色
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
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| 注意喚起語 |
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| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H413 |
長期的影響により水生生物に有害のおそれ |
水生環境有害性、慢性毒性 |
4 |
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| 注意書き |
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| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC3509 |
BMS493
BMS 493 |
215030-90-3 |
10mg |
￥79000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC3509 |
BMS493
BMS 493 |
215030-90-3 |
50mg |
￥330000 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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B6688 |
≥98% (HPLC)
BMS 493 ≥98% (HPLC) |
215030-90-3 |
5mg |
￥49800 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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B6688 |
≥98% (HPLC)
BMS 493 ≥98% (HPLC) |
215030-90-3 |
25mg |
￥149000 |
2024-03-01 |
購入 |
BMS493 化学特性,用途語,生産方法
説明
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 493 is a pan-RAR inverse agonist that blocks RARα activity with an IC
50 value of 114 nM. In all RAR types (RARα, RARβ, and RARγ), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions. BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.
使用
BMS 493 has been used:
- as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro
- for human induced pluripotent stem cells (iPSCs) culture and ventricular cardiomyocytes (VCMs) differentiation
- to inhibit retinoic acid (RA) signaling in explants
- as a retinoic acid receptor (RAR) inhibitor for the induction of synaptonemal complex protein 3 (SCP3) and ATP-dependent RNA helicase (DDX4) in primordial germ cells (PGCs)
一般的な説明
BMS 493 inhibits the formation of neuritic processes and plasmenyethanolamine -phospholipase A2 (PLA2) activity.
BMS493 上流と下流の製品情報
原材料
準備製品
BMS493 生産企業
Global( 47)Suppliers
215030-90-3(BMS493)キーワード:
- 215030-90-3
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
- BMS 493
- (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid
- BMS204, 493
- Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-
- (E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid
- BMS493,BMS-493
- BMS493
- 4-[2-[5,5-ジメチル-8-(フェニルエチニル)-5,6-ジヒドロナフタレン-2-イル]ビニル]安息香酸
- 4-{2-[5,5-ジメチル-8-(2-フェニルエチニル)-5,6-ジヒドロナフタレン-2-イル]エテニル}安息香酸