ビキニン
ビキニン 物理性質
- 融点 :
- 144°C(lit.)
- 沸点 :
- 521.6±45.0 °C(Predicted)
- 比重(密度) :
- 1.711
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：5mg/mL以上
- 酸解離定数(Pka):
- 4.59±0.10(Predicted)
- 外見 :
- 白い固体
- 色:
- 白から黄褐色
- InChIKey:
- XFYYQDHEDOXWGA-UHFFFAOYSA-N
- CAS データベース:
- 188011-69-0
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-9554 |
4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid |
188011-69-0 |
100mg |
￥16500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-9554 |
4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid |
188011-69-0 |
250mg |
￥24000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-9554 |
4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid |
188011-69-0 |
5g |
￥185000 |
2024-03-01 |
購入 |
|
東京化成工業
|
B4826 |
ビキニン >98.0%(HPLC)(T)
Bikinin
>98.0%(HPLC)(T) |
188011-69-0 |
25mg |
￥14400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0094 |
≥98% (HPLC)
Bikinin ≥98% (HPLC) |
188011-69-0 |
5mg |
￥22200 |
2024-03-01 |
購入 |
ビキニン 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
使用
Bikinin has been used:
- as a glycogen synthase kinase-3 (GSK3) inhibitor in Arabidopsis Col-0 seedlings to test its effect on gene expression
- as a component of induction medium and as a GSK3 inhibitor to test its effect on mesophyll cells in Arabidopsis leaf discs or cotyledons
- as a brassinosteroid agonist to test its effect on the leaf index of R. trichophyllus terrestrial leaves
Biochem/physiol Actions
Bikinin is a strong activator of brassinosteroid (BR) signaling. It is an Arabidopsis GSK-3 Inhibitor, an Arabidopsis SHAGGY-related Kinase Inhibitor, and a GSK-3-like Kinase BIN2 Inhibitor. Bikinin directly inhibits BIN2 (group II GSK3s) by interfering with ATP binding. Bikinin is specific toward a subset of Arabidopsis GSK3 kinases including BIN2 and ASK α, γ, ε, ι, and θ.
酵素阻害剤
This ATP-competitive Arabidopsis GSK-3 inhibitor, (FW = 273.08 g/mol; CAS 188011-69-0), also named 4-(5-bromopyridin-2-ylamino)-4- oxobutanoic acid, is a strong activator of brassinosteroid (BR) signaling. Bikinin directly binds the GSK3 BIN2 and also inhibits the activity of six other Arabidopsis GSK3s. Genome-wide transcript analyses demonstrate that simultaneous inhibition of seven GSK3s is sufficient to activate BR responses. inhibited the SnRK2.3 kinase activity and its T180 phosphorylation in vivo by blocking BIN2 phosphorylation of SnRK2.3 on Thr-180.
ビキニン 上流と下流の製品情報
原材料
準備製品
ビキニン 生産企業
Global( 128)Suppliers
188011-69-0(ビキニン)キーワード:
- 188011-69-0
- Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-
- Bikinin
- 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid
- 4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid
- Abrasin
- Bikinin(Abrasin)
- CS-1658
- Bikinin, >98%
- Bikinin - CAS 188011-69-0 - Calbiochem
- 4-[(5-Bromo-2-pyridyl)amino]-4-oxobutyric Acid
- Bikinin USP/EP/BP
- Bikinin, 7 Arabidopsis GSK-3 inhibitor
- Bikinin, 10 mM in DMSO
- ビキニン
- 4-[(5-ブロモ-2-ピリジル)アミノ]-4-オキソ酪酸