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N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

化学構造式
1256490-31-9
CAS番号.
1256490-31-9
化学名:
别名:
英語名:
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
英語别名:
EOS-61207;2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine;isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate;N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methyl...;N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este;N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester;(S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate;L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
CBNumber:
CB22604354
化学式:
C18H21N2O7P
分子量:
408.34
MOL File:
1256490-31-9.mol

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 物理性質

融点 :
62-66℃
沸点 :
514.3±60.0 °C(Predicted)
比重(密度) :
1.302
貯蔵温度 :
2-8°C
溶解性:
ジクロロメタン、酢酸エチル、メタノール
酸解離定数(Pka):
-5.78±0.70(Predicted)
外見 :
Solid
色:
White to off-white

安全性情報

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 化学特性,用途語,生産方法

使用

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 上流と下流の製品情報

原材料

準備製品

ソホスブビル

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 生産企業

Global( 42)Suppliers
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  • 1256490-31-9
  • N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
  • L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
  • 2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine
  • N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este
  • isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate
  • (S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate
  • N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methyl...
  • EOS-61207
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