Lパ2アンタゴニスト1 化学特性,用途語,生産方法
説明
LPA
2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA
2; IC
50 = 17 nM). It is selective for LPA
2 over LPA
1 and LPA
3 (IC
50s = >50 μM). LPA
2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner.
使用
N-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine is a Lpa2 protein antagonists.
Lパ2アンタゴニスト1 上流と下流の製品情報
原材料
準備製品