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AF-DX384

AF-DX384 化学構造式
118290-26-9
CAS番号.
118290-26-9
化学名:
AF-DX384
别名:
AF-DX384
英語名:
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
英語别名:
AF-DX-384; AF-DX384;AF-DX 384 Free Base;N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
CBNumber:
CB22751069
化学式:
C27H38N6O2
分子量:
478.63
MOL File:
118290-26-9.mol

AF-DX384 物理性質

沸点 :
618.4±55.0 °C(Predicted)
比重(密度) :
1.144±0.06 g/cm3(Predicted)
貯蔵温度 :
room temp
溶解性:
DMSO：可溶10mg/mL、透明（加温）
酸解離定数(Pka):
11.55±0.20(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

WGK Germany  3

AF-DX384 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC1345 AF-DX384
AF-DX 384 		118290-26-9 10mg ￥56000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC1345 AF-DX384
AF-DX 384 		118290-26-9 50mg ￥227000 2024-03-01 購入
Sigma-Aldrich Japan SML0620 ≥98% (HPLC)
AF-DX 384 Free Base ≥98% (HPLC)		 118290-26-9 5mg ￥18700 2024-03-01 購入
Sigma-Aldrich Japan SML0620 ≥98% (HPLC)
AF-DX 384 Free Base ≥98% (HPLC)		 118290-26-9 25mg ￥58640 2021-03-23 購入

AF-DX384 化学特性,用途語,生産方法

説明

AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

AF-DX384 上流と下流の製品情報

原材料

準備製品

AF-DX384 生産企業

Global( 15)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2784 58
BOC Sciences --
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
Absin Bioscience Inc. 021-38015121 15000105423
 wulan@absin.cn China 24734 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8141 58
Aikon International Limited 18626450290
 yftan@aikonchem.com China 10718 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 4679 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
 customer_service@efebio.com China 11975 58
  • 118290-26-9
  • AF-DX 384 Free Base
  • AF-DX-384; AF-DX384
  • N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
  • N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
  • 11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
  • AF-DX384
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