6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
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- CAS番号.
- 397864-40-3
- 化学名:
- 别名:
- 英語名:
- 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- 英語别名:
- GW675713X;BNKY012-FF04;Fluticasone furoate impurity 03;Fluticasone Carbothioic Acid Fuorate;6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid;6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid;6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid;6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)
- CBNumber:
- CB23372041
- 化学式:
- C26H28F2O6S
- 分子量:
- 506.56
- MOL File:
- 397864-40-3.mol
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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid 物理性質
- 融点 :
- >154°C (dec.)
- 沸点 :
- 622.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.38±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C Freezer, Under inert atmosphere
- 溶解性:
- クロロホルム（わずかに、加熱、超音波処理）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 2.97±0.70(Predicted)
- 色:
- ホワイトからオフホワイト
- 安定性：:
- 空気に敏感
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid 価格
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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid 化学特性,用途語,生産方法
使用
(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid is a steroid used in the preparation of crystalline forms of the therapeutically useful anti-inflammatory corticosteroid fluticasone furoate (I) and its solvates. A fluticasone furoate (F599510) impurity.
合成
A suspension of 17β-[(N, N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene (14.2 g, 0.024 mol) and potassium carbonate (6.78 g, 0.0491 mol) in methanol (70 ml) was stirred at ambient temperature for 6 hrs under a blanket of nitrogen. After that, water was added to the reaction mixture, and the clear solution was washed with toluene. The aqueous layer containing the product was charcoalized and then acidified with 2N HCl until pH was 1.5 to 2.0. The precipitated product was filtered, washed with water, and dried to yield 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid as a white solid (11.8 g, 94.8%).
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid 上流と下流の製品情報
原材料
準備製品
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid 生産企業
Global( 29)Suppliers
397864-40-3()キーワード:
2-[3-オキソ-5-(2,3-ジヒドロ-1H-ペリミジン-2-イル)-6-ヒドロキシ-3H-キサンテン-9-イル]安息香酸
フルチカゾン
(7R,8R,9S,13S,14S,17S)-13-メチル-7-(9-((4,4,5,5,5-ペンタフルオロペンチル)チオ)ノニル)-7,8,9,11,12,13,14,15,16,17-デカヒドロ-6H-シクロペンタ[A]フェナントレン-3,17-ジオール
フロ酸フルチカソン
- 397864-40-3
- 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- BNKY012-FF04
- GW675713X
- Fluticasone Carbothioic Acid Fuorate
- Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
- (6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)
- 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- Fluticasone Thioacid-17-furoateQ: What is
Fluticasone Thioacid-17-furoate Q: What is the CAS Number of
Fluticasone Thioacid-17-furoate
- 6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid
- Fluticasone furoate impurity 03
- 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid
- Fluticasone Impurity(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid)