抗VASP(C末端)抗体 ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-VASP (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
一般的な説明
Vasodilator stimulated phosphoprotein (VASP) is encoded by the gene mapped to human chromosome 19q13.32. The encoded protein belongs to the Ena/VASP protein family. VASP is characterized with an N-terminal EVH1 domain, C-terminal EVH2 domain and proline-rich region.
Biochem/physiol Actions
Vasodilator stimulated phosphoprotein (VASP) acts as an actin-polymerization regulator and plays a vital role in regulation of cell migration by interacting with Migfilin, a cell-extracellular matrix (ECM) adhesion protein. Elevated expression of VASP contributes to the development of breast cancer (BC). Hence, this protein can be used as a potential biomarker for BC metastasis. Phosphorylation of VASP by protein kinase A (PKA) at phosphorylation site S157 aids in localization of cell periphery into focal adhesions, but phosphorylation of VASP at S239 and T278 aids in regulation of F-actin assembly.
抗VASP(C末端)抗体 ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品