17-PHENYL TRINOR PGF2ALPHA-IPR

 化学構造式
130209-76-6
CAS番号.
130209-76-6
化学名:
别名:
英語名:
17-PHENYL TRINOR PGF2ALPHA-IPR
英語别名:
13-trans-Latanoprost;Sparsentan Impurity 17;Bimatoprost isopropyl este;imatoprost isopropyl ester;Bimatoprost isopropyl ester;17-PHENYL TRINOR PGF2ALPHA-IPR;Bimatoprost Acid Isopropyl Ester;17-phenyl trinor PGF2α isopropyl ester;17-phenyl trinor PGF2alpha isopropyl ester;17-phenyl trinor Prostaglandin F2α isopropyl ester
CBNumber:
CB2459437
化学式:
C26H38O5
分子量:
430.58
MOL File:
130209-76-6.mol

17-PHENYL TRINOR PGF2ALPHA-IPR 物理性質

沸点 :
573.4±50.0 °C(Predicted)
比重(密度) :
1.141
貯蔵温度 :
Store at -20°C
溶解性:
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml
酸解離定数(Pka):
14.25±0.20(Predicted)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
絵表示(GHS) GHS hazard pictogramsGHS hazard pictograms
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険 GHS hazard pictograms
注意書き

17-PHENYL TRINOR PGF2ALPHA-IPR 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

17-PHENYL TRINOR PGF2ALPHA-IPR 化学特性,用途語,生産方法

説明

17-phenyl trinor PGF N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.

17-PHENYL TRINOR PGF2ALPHA-IPR 上流と下流の製品情報

原材料

準備製品


17-PHENYL TRINOR PGF2ALPHA-IPR 生産企業

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130209-76-6()キーワード:


  • 130209-76-6
  • 17-phenyl-18,19,20-trinor-prostaglandinf2alpha-1-isopropylester
  • 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
  • 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
  • 17-PHENYL TRINOR PGF2ALPHA-IPR
  • 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester
  • Bimatoprost isopropyl ester
  • 17-phenyl trinor Prostaglandin F2α isopropyl ester
  • 17-phenyl trinor PGF2α isopropyl ester
  • isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate
  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-5-heptenoic acid propan-2-yl ester
  • propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate
  • Bimatoprost isopropyl este
  • imatoprost isopropyl ester
  • 17-phenyl trinor PGF2alpha isopropyl ester
  • Bimatoprost Acid Isopropyl Ester
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
  • 13-trans-Latanoprost
  • isopropyl phenylhydroxypentene dihydroxycyclopentylheptenate
  • 17-phenyl trinor Prostaglandin F2α isopropyl ester
  • Sparsentan Impurity 17
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