安息香酸デナトニウム 化学特性,用途語,生産方法
外観
白色〜ほとんど白色, 結晶〜粉末
定義
本品は、芳香族化合物であり次の化学式で表される。
溶解性
エタノールに溶けやすく、水にやや溶けやすく、アセトンにやや溶けにくい。
解説
安息香酸デナトニウムは，芳香族化合物の一つであるデナトニウムと安息香酸との塩。無臭の白色固体。極めて強い苦みをもつことで知られ、幼児などによる誤飲防止のための添加物として利用される。デナトニウムベンゾエイト。化学式C28H34N2O3
小学館 デジタル大辞泉について 情報 | 凡例
用途
洗剤、カーペット用シャンプー、アルコール、燈油、マニキュア液の変性剤として使用。
化粧品の成分用途
変性剤、香料
化学的特性
white crystals
調製方法
Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
応用例（製薬）
Denatonium benzoate is among the most bitter of substances
known and is detectable at concentrations of approximately 10 ppb.
In pharmaceutical and other industrial applications it is added to
some products as a deterrent to accidental ingestion. It is most
commonly used at levels of 5–500 ppm. Denatonium benzoate may
also be used to replace brucine or quassin as a denaturant for
ethanol.
In pharmaceutical formulations, denatonium benzoate has been
used as a flavoring agent in placebo tablets, and in a topical
formulation it has been used in an anti-nailbiting preparation.
安全性
Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
合成
A method for synthesizing Denatonium Benzoate comprises the following steps: (1) adding benzyl halide to a reactor containing raw material lidocaine under stirring and at a certain temperature, wherein the reaction temperature is from room temperature to 130°C, and the ratio of lidocaine to benzyl halide is 1:1 to 1:2; (2) after the reaction is complete, adding solvent and metal hydroxide; (3) adding benzoic acid, after the reaction is completed, the generated benzyl ammonium benzoate is filtered, washed, concentrated, and washed to obtain the product benzyl ammonium benzoate.
貯蔵
Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
不和合性
Denatonium benzoateis incompatible with strongoxidizing agents.
規制状況(Regulatory Status)
Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).
安息香酸デナトニウム 上流と下流の製品情報
原材料
準備製品