10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸

10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸 化学特性,用途語,生産方法

Originator

Migristene,Rhone Poulenc,France,1965

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸 上流と下流の製品情報

原材料

準備製品

10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

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• 13115-40-7
• Yoristen
• IL-6302
• N,N-Dimethyl-10-[2-(dimethylamino)propyl]-10H-phenothiazine-2-sulfonamide·methanesulfonic acid
• 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate
• 10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide methanesulfonate
• 10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-, monomethanesulfonate
• 8599RP mesylate
• Banistyl
• Bonpac
• Calsekin
• Dimethothiazine mesylate
• Dimethothiazine methanesulfonate
• dimetotiazine mesilate
• Fonazine mesylate
• Fonazine methanesulfonate
• IL 6302 mesylate
• Migristene
• Neomestine
• Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-, monomethanesulfonate (8CI)
• Promaquid
• RP 8599
• RP 8599 mesylate
• プロマキド
• ホナジンメシラート
• 10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸
• メシル酸ジメトチアジン
• ジメトチアジンメシル酸塩
• ヨリステン
• ネオメスチン
• ミグリステン
• N,N-ジメチル-10-[2-(ジメチルアミノ)プロピル]-10H-フェノチアジン-2-スルホンアミド·メタンスルホン酸
• N,N-ジメチル-10-[2-(ジメチルアミノ)プロピル]-10H-フェノチアジン-2-スルホンアミド・メタンスルホン酸
• 10-[2-(ジメチルアミノ)プロピル]-N,N-ジメチル-10H-フェノチアジン-2-スルホンアミド・メタンスルホン酸
• セロトニン拮抗薬
• 鎮痛薬